Insulin binding on molt 4 cells: Effect of a sulfonylurea

Renzo Cordera, Giovanna Chimini, Marcello Bagnasco, Roberto Gherzi

Research output: Contribution to journalArticle

Abstract

Cultured neoplastic cell lines are widely considered an adequate model for insulin receptor studies. In this work the insulin receptor of a well-known continuous T-cell line (MOLT 4) was characterized. These cells showed specific insulin receptor with binding properties quite similar to those of other lymphoblastoid cells. Therefore, we used MOLT 4 receptor to evaluate the effect of the sulfonylurea glipizide on insulin binding. After a 24-hour preliminary incubation of cells with glipizide, we found a 44% increase of insulin receptor binding apparently due to an increase of insulin binding sites.

Original languageEnglish
Pages (from-to)246-251
Number of pages6
JournalHormone Research in Paediatrics
Volume20
Issue number4
DOIs
Publication statusPublished - 1984

Keywords

  • Glipizide
  • Insulin receptor
  • Neoplastic cell line

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

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