La controregolazione insulare nella sclerosi multipla.

Translated title of the contribution: Insulin counter-regulation in multiple sclerosis

V. Procacci, R. A. Altavilla, M. G. Roberto, D. Chicco, N. Antonacci, G. Vendemiale, E. Altomare

Research output: Contribution to journalArticlepeer-review


Fasting hypoglycemia is frequently observed in patients with Multiple Sclerosis (S.M.) showing orthostatic hypotension and defective thermoregulation, although they never complicate in hypoglycemic coma. The aim of this study was to evaluate glucose homeostasis in S.M. patients. Both insular and counter-insular regulating mechanisms were investigated by determination of glucose, insulin, C-peptide and cortisol plasmatic levels during OGTT, and subsequently by evaluating glucagon plasmatic levels after arginine administration (30 g., i.v.). Our results suggest that the increased susceptibility of S.M. patients to undergo fasting hypoglycemia could be related to some alterations in counter-insular mechanisms, generally included among neurovegetative modifications in S.M. patients and probably due to orthosympathetic function impairment.

Translated title of the contributionInsulin counter-regulation in multiple sclerosis
Original languageItalian
Pages (from-to)795-802
Number of pages8
JournalBollettino della Societa Italiana di Biologia Sperimentale
Issue number8
Publication statusPublished - Aug 1990

ASJC Scopus subject areas

  • Medicine(all)

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