La controregolazione insulare nella sclerosi multipla.

Translated title of the contribution: Insulin counter-regulation in multiple sclerosis

V. Procacci, R. A. Altavilla, M. G. Roberto, D. Chicco, N. Antonacci, G. Vendemiale, E. Altomare

Research output: Contribution to journalArticle

Abstract

Fasting hypoglycemia is frequently observed in patients with Multiple Sclerosis (S.M.) showing orthostatic hypotension and defective thermoregulation, although they never complicate in hypoglycemic coma. The aim of this study was to evaluate glucose homeostasis in S.M. patients. Both insular and counter-insular regulating mechanisms were investigated by determination of glucose, insulin, C-peptide and cortisol plasmatic levels during OGTT, and subsequently by evaluating glucagon plasmatic levels after arginine administration (30 g., i.v.). Our results suggest that the increased susceptibility of S.M. patients to undergo fasting hypoglycemia could be related to some alterations in counter-insular mechanisms, generally included among neurovegetative modifications in S.M. patients and probably due to orthosympathetic function impairment.

Original languageItalian
Pages (from-to)795-802
Number of pages8
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume66
Issue number8
Publication statusPublished - Aug 1990

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Procacci, V., Altavilla, R. A., Roberto, M. G., Chicco, D., Antonacci, N., Vendemiale, G., & Altomare, E. (1990). La controregolazione insulare nella sclerosi multipla. Bollettino della Societa Italiana di Biologia Sperimentale, 66(8), 795-802.