Abstract
Objective: The aim of the present study was to evaluate the association between the type of early feeding and indices of insulin metabolism in 8-year-old overweight and obese children. Methods: The sample included 350 overweight (body mass index [BMI] ≥1.036 standard deviation score [SDS]) and obese (BMI ≥1.645 SDS) children and 33 normal-weight control subjects who had been exclusively breast-fed or formula-fed for 4 months or longer. Parameters of insulin sensitivity and secretion were derived from 120-minute oral glucose tolerance tests. Results: Overweight and obese formula-fed children (N = 165) were more insulin resistant than breast-fed individuals (N=185; Whole-Body Insulin Sensitivity Index 5.1 ± 2.3 vs 6.± 6 2; p, 0.0001) despite having the same degree of obesity (BMI z-score 1.8 6 0.4 vs 1.7 6 0.4 SDS; p = 0.5). They compensated for enhanced insulin resistance by augmenting insulin secretion (Insulinogenic Index 6.8 ± 3.6 vs 5.2 ± 2.5μlIU/mL × mg/mL × 1; p, 0.0001). Thus, they presented with a disposition index similar to that of breast-fed children (34.6 ± 15 vs 30.8 ± 19.2; p = 0.4), Formula feeding was associated with greater catch-up growth in the first month (odds ratio 2.49, 95% confidence interval 1.97 to 3.01; p
| Original language | English |
|---|---|
| Pages (from-to) | 29-38 |
| Number of pages | 10 |
| Journal | Journal of the American College of Nutrition |
| Volume | 30 |
| Issue number | 1 |
| Publication status | Published - Feb 2011 |
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Keywords
- Breast-feeding
- Catch-up growth
- Formula feeding
- Insulin resistance
- Insulin secretion
- Obesity
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Insulin dynamics of breast- or formula-fed overweight and obese children. / Manco, Melania; Alterio, Arianna; Bugianesi, Elisabetta; Ciampalini, Paolo; Mariani, Paolo; Finocchi, Maurizio; Agostoni, Carlo; Nobili, Valerio.
In: Journal of the American College of Nutrition, Vol. 30, No. 1, 02.2011, p. 29-38.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin dynamics of breast- or formula-fed overweight and obese children
AU - Manco, Melania
AU - Alterio, Arianna
AU - Bugianesi, Elisabetta
AU - Ciampalini, Paolo
AU - Mariani, Paolo
AU - Finocchi, Maurizio
AU - Agostoni, Carlo
AU - Nobili, Valerio
PY - 2011/2
Y1 - 2011/2
N2 - Objective: The aim of the present study was to evaluate the association between the type of early feeding and indices of insulin metabolism in 8-year-old overweight and obese children. Methods: The sample included 350 overweight (body mass index [BMI] ≥1.036 standard deviation score [SDS]) and obese (BMI ≥1.645 SDS) children and 33 normal-weight control subjects who had been exclusively breast-fed or formula-fed for 4 months or longer. Parameters of insulin sensitivity and secretion were derived from 120-minute oral glucose tolerance tests. Results: Overweight and obese formula-fed children (N = 165) were more insulin resistant than breast-fed individuals (N=185; Whole-Body Insulin Sensitivity Index 5.1 ± 2.3 vs 6.± 6 2; p, 0.0001) despite having the same degree of obesity (BMI z-score 1.8 6 0.4 vs 1.7 6 0.4 SDS; p = 0.5). They compensated for enhanced insulin resistance by augmenting insulin secretion (Insulinogenic Index 6.8 ± 3.6 vs 5.2 ± 2.5μlIU/mL × mg/mL × 1; p, 0.0001). Thus, they presented with a disposition index similar to that of breast-fed children (34.6 ± 15 vs 30.8 ± 19.2; p = 0.4), Formula feeding was associated with greater catch-up growth in the first month (odds ratio 2.49, 95% confidence interval 1.97 to 3.01; p
AB - Objective: The aim of the present study was to evaluate the association between the type of early feeding and indices of insulin metabolism in 8-year-old overweight and obese children. Methods: The sample included 350 overweight (body mass index [BMI] ≥1.036 standard deviation score [SDS]) and obese (BMI ≥1.645 SDS) children and 33 normal-weight control subjects who had been exclusively breast-fed or formula-fed for 4 months or longer. Parameters of insulin sensitivity and secretion were derived from 120-minute oral glucose tolerance tests. Results: Overweight and obese formula-fed children (N = 165) were more insulin resistant than breast-fed individuals (N=185; Whole-Body Insulin Sensitivity Index 5.1 ± 2.3 vs 6.± 6 2; p, 0.0001) despite having the same degree of obesity (BMI z-score 1.8 6 0.4 vs 1.7 6 0.4 SDS; p = 0.5). They compensated for enhanced insulin resistance by augmenting insulin secretion (Insulinogenic Index 6.8 ± 3.6 vs 5.2 ± 2.5μlIU/mL × mg/mL × 1; p, 0.0001). Thus, they presented with a disposition index similar to that of breast-fed children (34.6 ± 15 vs 30.8 ± 19.2; p = 0.4), Formula feeding was associated with greater catch-up growth in the first month (odds ratio 2.49, 95% confidence interval 1.97 to 3.01; p
KW - Breast-feeding
KW - Catch-up growth
KW - Formula feeding
KW - Insulin resistance
KW - Insulin secretion
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=79960377570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960377570&partnerID=8YFLogxK
M3 - Article
C2 - 21697536
AN - SCOPUS:79960377570
VL - 30
SP - 29
EP - 38
JO - Journal of the American College of Nutrition
JF - Journal of the American College of Nutrition
SN - 0731-5724
IS - 1
ER -