Abstract
Regular or crystalline insulin with sodium glycocholate as surfactant administered intranasally to normal volunteers induced hypoglycaemia and an increase in serum immunoreactive insulin concentrations. Serum C-peptide concentrations decreased or remained unchanged. Insulin administered intravenously to three of these subjects yielded a potency ratio of 1:8 for intranasal and intravenous insulin. In four insulin-dependent diabetics a cross-over study was performed on different days, insulin being administered once intranasally and once subcutaneously in a ratio of 1:9. In these patients the intranasal insulin was more effective than the subcutaneous insulin in preventing hyperglycaemia after breakfast. In four other insulin-dependent diabetics 11-hour monitoring was performed twice on two different days, insulin being administered in divided dosage sufficient to achieve a reasonable glycaemic profile. The average control was similar with the two routes of administration during the morning, whereas subcutaneous insulin was more effective than intranasal during the afternoon.
| Original language | English |
|---|---|
| Pages (from-to) | 303-306 |
| Number of pages | 4 |
| Journal | British Medical Journal |
| Volume | 284 |
| Issue number | 6312 |
| Publication status | Published - 1982 |
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Cite this
Insulin given intranasally induces hypoglycaemia in normal and diabetic subjects. / Pontiroli, A. E.; Alberetto, M.; Secchi, A.; Dossi, G.; Bosi, I.; Pozza, G.
In: British Medical Journal, Vol. 284, No. 6312, 1982, p. 303-306.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin given intranasally induces hypoglycaemia in normal and diabetic subjects
AU - Pontiroli, A. E.
AU - Alberetto, M.
AU - Secchi, A.
AU - Dossi, G.
AU - Bosi, I.
AU - Pozza, G.
PY - 1982
Y1 - 1982
N2 - Regular or crystalline insulin with sodium glycocholate as surfactant administered intranasally to normal volunteers induced hypoglycaemia and an increase in serum immunoreactive insulin concentrations. Serum C-peptide concentrations decreased or remained unchanged. Insulin administered intravenously to three of these subjects yielded a potency ratio of 1:8 for intranasal and intravenous insulin. In four insulin-dependent diabetics a cross-over study was performed on different days, insulin being administered once intranasally and once subcutaneously in a ratio of 1:9. In these patients the intranasal insulin was more effective than the subcutaneous insulin in preventing hyperglycaemia after breakfast. In four other insulin-dependent diabetics 11-hour monitoring was performed twice on two different days, insulin being administered in divided dosage sufficient to achieve a reasonable glycaemic profile. The average control was similar with the two routes of administration during the morning, whereas subcutaneous insulin was more effective than intranasal during the afternoon.
AB - Regular or crystalline insulin with sodium glycocholate as surfactant administered intranasally to normal volunteers induced hypoglycaemia and an increase in serum immunoreactive insulin concentrations. Serum C-peptide concentrations decreased or remained unchanged. Insulin administered intravenously to three of these subjects yielded a potency ratio of 1:8 for intranasal and intravenous insulin. In four insulin-dependent diabetics a cross-over study was performed on different days, insulin being administered once intranasally and once subcutaneously in a ratio of 1:9. In these patients the intranasal insulin was more effective than the subcutaneous insulin in preventing hyperglycaemia after breakfast. In four other insulin-dependent diabetics 11-hour monitoring was performed twice on two different days, insulin being administered in divided dosage sufficient to achieve a reasonable glycaemic profile. The average control was similar with the two routes of administration during the morning, whereas subcutaneous insulin was more effective than intranasal during the afternoon.
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M3 - Article
C2 - 6800439
AN - SCOPUS:0020051102
VL - 284
SP - 303
EP - 306
JO - British Medical Journal
JF - British Medical Journal
SN - 0959-8146
IS - 6312
ER -