Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia

Francesco Maura, Laura Mosca, Sonia Fabris, Giovanna Cutrona, Serena Matis, Marta Lionetti, Luca Agnelli, Marzia Barbieri, Marianna D'Anca, Martina Manzoni, Monica Colombo, Carlotta Massucco, Daniele Reverberi, Massimo Gentile, Anna Grazia Recchia, Sabrina Bossio, Fiorella Ilariucci, Caterina Musolino, Francesco Di Raimondo, Agostino CortelezziFortunato Morabito, Manlio Ferrarini, Antonino Neri

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Abstract

IGF1R is emerging as an important gene in the pathogenesis of many solid and haematological cancers and its over-expression has been reported as frequently associated with aggressive disease and chemotherapy resistance. In this study we performed an investigation of the role of IGF1R expression in a large and representative prospective series of 217 chronic lymphocytic leukaemia (CLL) patients enrolled in the multicentre O-CLL1 protocol (clinicaltrial.gov #NCT00917540). High IGF1R gene expression was significantly associated with IGHV unmutated (IGHV-UM) status (p

Original languageEnglish
Article numbere0118801
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 18 2015

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Maura, F., Mosca, L., Fabris, S., Cutrona, G., Matis, S., Lionetti, M., Agnelli, L., Barbieri, M., D'Anca, M., Manzoni, M., Colombo, M., Massucco, C., Reverberi, D., Gentile, M., Recchia, A. G., Bossio, S., Ilariucci, F., Musolino, C., Di Raimondo, F., ... Neri, A. (2015). Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia. PLoS One, 10(3), [e0118801]. https://doi.org/10.1371/journal.pone.0118801