INSULIN KINETICS: INSIGHT FROM COMPARTMENTAL MODELING AND DECONVOLUTION.

A. Caumo, C. Cobelli, M. P. Saccomani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The authors describe models for interpreting insulin kinetics in humans. Salient features of a novel experiment design which allows the study of the kinetics after both intravenous (iv) and subcutaneous (sc) administration are described. Compartmental models are discussed for interpreting iv data in normal and diabetic humans: a two-compartment representation is shown to be the most adequate. Some aspects of a recently proposed deconvolution approach for reconstructing the rate of appearance of insulin after sc administration are discussed.

Original languageEnglish
Title of host publicationIEEE/Engineering in Medicine and Biology Society Annual Conference
PublisherIEEE
Pages713-718
Number of pages6
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Engineering(all)

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