The authors describe models for interpreting insulin kinetics in humans. Salient features of a novel experiment design which allows the study of the kinetics after both intravenous (iv) and subcutaneous (sc) administration are described. Compartmental models are discussed for interpreting iv data in normal and diabetic humans: a two-compartment representation is shown to be the most adequate. Some aspects of a recently proposed deconvolution approach for reconstructing the rate of appearance of insulin after sc administration are discussed.
|Title of host publication||IEEE/Engineering in Medicine and Biology Society Annual Conference|
|Number of pages||6|
|Publication status||Published - 1986|
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