Abstract
The authors describe models for interpreting insulin kinetics in humans. Salient features of a novel experiment design which allows the study of the kinetics after both intravenous (iv) and subcutaneous (sc) administration are described. Compartmental models are discussed for interpreting iv data in normal and diabetic humans: a two-compartment representation is shown to be the most adequate. Some aspects of a recently proposed deconvolution approach for reconstructing the rate of appearance of insulin after sc administration are discussed.
| Original language | English |
|---|---|
| Title of host publication | IEEE/Engineering in Medicine and Biology Society Annual Conference |
| Publisher | IEEE |
| Pages | 713-718 |
| Number of pages | 6 |
| Publication status | Published - 1986 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
INSULIN KINETICS : INSIGHT FROM COMPARTMENTAL MODELING AND DECONVOLUTION. / Caumo, A.; Cobelli, C.; Saccomani, M. P.
IEEE/Engineering in Medicine and Biology Society Annual Conference. IEEE, 1986. p. 713-718.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - INSULIN KINETICS
T2 - INSIGHT FROM COMPARTMENTAL MODELING AND DECONVOLUTION.
AU - Caumo, A.
AU - Cobelli, C.
AU - Saccomani, M. P.
PY - 1986
Y1 - 1986
N2 - The authors describe models for interpreting insulin kinetics in humans. Salient features of a novel experiment design which allows the study of the kinetics after both intravenous (iv) and subcutaneous (sc) administration are described. Compartmental models are discussed for interpreting iv data in normal and diabetic humans: a two-compartment representation is shown to be the most adequate. Some aspects of a recently proposed deconvolution approach for reconstructing the rate of appearance of insulin after sc administration are discussed.
AB - The authors describe models for interpreting insulin kinetics in humans. Salient features of a novel experiment design which allows the study of the kinetics after both intravenous (iv) and subcutaneous (sc) administration are described. Compartmental models are discussed for interpreting iv data in normal and diabetic humans: a two-compartment representation is shown to be the most adequate. Some aspects of a recently proposed deconvolution approach for reconstructing the rate of appearance of insulin after sc administration are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0022957888&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022957888&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0022957888
SP - 713
EP - 718
BT - IEEE/Engineering in Medicine and Biology Society Annual Conference
PB - IEEE
ER -