Insulin-like growth factor-1 bioactivity plays a prosurvival role in older participants

Marcello Maggio, Chiara Cattabiani, Fulvio Lauretani, Stefania Bandinelli, Francesca De Vita, Elisabetta Dall'Aglio, Andrea Corsonello, Fabrizia Lattanzio, Giuseppe Paolisso, Luigi Ferrucci, Gian Paolo Ceda

Research output: Contribution to journalArticlepeer-review


The aim of this study was to address the intriguing issue of the role of the insulin-like growth factor (IGF)-1 system in longevity looking at the role of different components of IGF system. Vital status was ascertained in 1,197 men and women aged greater than or equal to 65 years from the InCHIANTI study. Hormonal levels were categorized into quartiles, and ratio of IGF-1 to IGF-binding protein (IGFBP)-1 was calculated. The relationship between hormones and mortality was tested by Cox proportional hazard models adjusted for age, sex, and confounders. During the 8-year follow-up period, 240 died and 957 survived. Lowest quartiles of IGF-1 and IGFBP-1 were considered as reference. Compared with the lowest quartiles, IGF-1 in upper quartiles was a negative predictor of mortality independent of age and sex (p =. 01) but not independent of IGFBP-1 and other confounders. IGFBP-1 in second-third quartiles was negatively associated and that in the fourth quartiles was positively associated with risk of death. IGF-1/IGFBP-1 ratio in the lowest quartiles was a strong positive predictor of mortality, in age- and sex-adjusted model (p =. 005), and independent of additional confounders (p =. 037). High IGFBP-1 and low IGF-1/IGFBP-1 ratio are associated with all-cause mortality in older population.

Original languageEnglish
Pages (from-to)1342-1350
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number11
Publication statusPublished - Nov 2013


  • IGF-1 bioactivity
  • IGF-binding proteins
  • Mortality
  • Older participants

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Medicine(all)


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