Insulin-like growth factor-1 deficiency determines increased intima-media thickness at common carotid arteries in adult patients with growth hormone deficiency

Annamaria Colao, Carolina Di Somma, Mariagiovanna Filippella, Francesca Rota, Rosario Pivonello, Francesco Orio, Giovanni Vitale, Gaetano Lombardi

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To investigate the role of IGF-1 on intima-media thickness (IMT) at common carotid arteries by Doppler ultrasonography. SUBJECTS: Thirty-nine patients (17 women, 22 men, aged 25-70 years) with severe GH deficiency (GHD), 19 with normal and 20 with low IGF-1 levels, and 39 sex-, age- and body mass index (BMI)-matched healthy controls. RESULTS: Patients with GHD showed abnormalities in lipid profile, and increased fibrinogen levels, mean IMT (0.88 ± 0.26 vs. 0.69 ± 0.14 mm, P <0.001), and systolic and diastolic peak velocity (P <0.001) compared to controls. Eight patients (18%) and one control (2.1%, P = 0.04) had well-defined plaques. In controls, but not in patients with GHD, mean carotid IMT was correlated with age (r = 0.78, P <0.001). In both controls (r = -0.82; P <0.0001) and patients with GHD (r = -0.84, P <0.0001), serum IGF-1 levels were inversely correlated with mean IMT at common carotid arteries. At the stepwise multiple regression, the variables most significantly related to IMT in GH-deficient patients were total cholesterol levels (t = 5.2, P <0.001), followed by disease duration (t = 2.4, P = 0.02), while in controls the variables most significantly related to IMT were IGF-1 levels (t = -9.9, P <0.001), followed by low density lipoprotein (LDL)-cholesterol levels (t = -2.3, P = 0.02). Compared to patients with normal IGF-1 levels, those with low IGF-1 levels had lower high density lipoprotein (HDL)-cholesterol levels (1.0 ± 0.2 vs. 1.3 ± 0.2 mmol/l, P = 0.0002), and higher glucose (54.3 ± 6.1 vs. 48.9 ± 5.9 mmol/l, P = 0.008), insulin (25.2 ± 6.8 vs. 18.8 ± 6.0 mUl/l, P = 0.004), total cholesterol (7.1 ± 1.1 vs. 4.9 ± 0.6 mmol/l, P <0.0001), total/HDL-cholesterol ratio (7.2 ± 1.8 vs. 3.9 ± 0.7, P <0.0001), fibrinogen levels (319.8 ± 56.9 vs. 241.8 ± 53.0 mg/dl, P <0.0001) and mean IMT at common carotid arteries (1.05 ± 0.25 vs. 0.69 ± 0.07 mm, P <0.0001). Atherosclerotic plaques were found only in GH-deficient patients with low IGF-1 levels. CONCLUSlONS: GH-deficient patients have alterations in lipid profile with an increase in the total/HDL-cholesterol ratio, which is an index of increased cardiovascular risk, but only patients with IGF-1 deficiency have increased IMT.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
JournalClinical Endocrinology
Volume61
Issue number3
DOIs
Publication statusPublished - Sep 2004

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Common Carotid Artery
Somatomedins
Growth Hormone
Insulin-Like Growth Factor I
HDL Cholesterol
Fibrinogen
Cholesterol
Lipids
Doppler Ultrasonography
Carotid Intima-Media Thickness
Atherosclerotic Plaques
LDL Cholesterol
Body Mass Index
Insulin
Glucose

ASJC Scopus subject areas

  • Endocrinology

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Insulin-like growth factor-1 deficiency determines increased intima-media thickness at common carotid arteries in adult patients with growth hormone deficiency. / Colao, Annamaria; Di Somma, Carolina; Filippella, Mariagiovanna; Rota, Francesca; Pivonello, Rosario; Orio, Francesco; Vitale, Giovanni; Lombardi, Gaetano.

In: Clinical Endocrinology, Vol. 61, No. 3, 09.2004, p. 360-366.

Research output: Contribution to journalArticle

Colao, Annamaria ; Di Somma, Carolina ; Filippella, Mariagiovanna ; Rota, Francesca ; Pivonello, Rosario ; Orio, Francesco ; Vitale, Giovanni ; Lombardi, Gaetano. / Insulin-like growth factor-1 deficiency determines increased intima-media thickness at common carotid arteries in adult patients with growth hormone deficiency. In: Clinical Endocrinology. 2004 ; Vol. 61, No. 3. pp. 360-366.
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T1 - Insulin-like growth factor-1 deficiency determines increased intima-media thickness at common carotid arteries in adult patients with growth hormone deficiency

AU - Colao, Annamaria

AU - Di Somma, Carolina

AU - Filippella, Mariagiovanna

AU - Rota, Francesca

AU - Pivonello, Rosario

AU - Orio, Francesco

AU - Vitale, Giovanni

AU - Lombardi, Gaetano

PY - 2004/9

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N2 - OBJECTIVE: To investigate the role of IGF-1 on intima-media thickness (IMT) at common carotid arteries by Doppler ultrasonography. SUBJECTS: Thirty-nine patients (17 women, 22 men, aged 25-70 years) with severe GH deficiency (GHD), 19 with normal and 20 with low IGF-1 levels, and 39 sex-, age- and body mass index (BMI)-matched healthy controls. RESULTS: Patients with GHD showed abnormalities in lipid profile, and increased fibrinogen levels, mean IMT (0.88 ± 0.26 vs. 0.69 ± 0.14 mm, P <0.001), and systolic and diastolic peak velocity (P <0.001) compared to controls. Eight patients (18%) and one control (2.1%, P = 0.04) had well-defined plaques. In controls, but not in patients with GHD, mean carotid IMT was correlated with age (r = 0.78, P <0.001). In both controls (r = -0.82; P <0.0001) and patients with GHD (r = -0.84, P <0.0001), serum IGF-1 levels were inversely correlated with mean IMT at common carotid arteries. At the stepwise multiple regression, the variables most significantly related to IMT in GH-deficient patients were total cholesterol levels (t = 5.2, P <0.001), followed by disease duration (t = 2.4, P = 0.02), while in controls the variables most significantly related to IMT were IGF-1 levels (t = -9.9, P <0.001), followed by low density lipoprotein (LDL)-cholesterol levels (t = -2.3, P = 0.02). Compared to patients with normal IGF-1 levels, those with low IGF-1 levels had lower high density lipoprotein (HDL)-cholesterol levels (1.0 ± 0.2 vs. 1.3 ± 0.2 mmol/l, P = 0.0002), and higher glucose (54.3 ± 6.1 vs. 48.9 ± 5.9 mmol/l, P = 0.008), insulin (25.2 ± 6.8 vs. 18.8 ± 6.0 mUl/l, P = 0.004), total cholesterol (7.1 ± 1.1 vs. 4.9 ± 0.6 mmol/l, P <0.0001), total/HDL-cholesterol ratio (7.2 ± 1.8 vs. 3.9 ± 0.7, P <0.0001), fibrinogen levels (319.8 ± 56.9 vs. 241.8 ± 53.0 mg/dl, P <0.0001) and mean IMT at common carotid arteries (1.05 ± 0.25 vs. 0.69 ± 0.07 mm, P <0.0001). Atherosclerotic plaques were found only in GH-deficient patients with low IGF-1 levels. CONCLUSlONS: GH-deficient patients have alterations in lipid profile with an increase in the total/HDL-cholesterol ratio, which is an index of increased cardiovascular risk, but only patients with IGF-1 deficiency have increased IMT.

AB - OBJECTIVE: To investigate the role of IGF-1 on intima-media thickness (IMT) at common carotid arteries by Doppler ultrasonography. SUBJECTS: Thirty-nine patients (17 women, 22 men, aged 25-70 years) with severe GH deficiency (GHD), 19 with normal and 20 with low IGF-1 levels, and 39 sex-, age- and body mass index (BMI)-matched healthy controls. RESULTS: Patients with GHD showed abnormalities in lipid profile, and increased fibrinogen levels, mean IMT (0.88 ± 0.26 vs. 0.69 ± 0.14 mm, P <0.001), and systolic and diastolic peak velocity (P <0.001) compared to controls. Eight patients (18%) and one control (2.1%, P = 0.04) had well-defined plaques. In controls, but not in patients with GHD, mean carotid IMT was correlated with age (r = 0.78, P <0.001). In both controls (r = -0.82; P <0.0001) and patients with GHD (r = -0.84, P <0.0001), serum IGF-1 levels were inversely correlated with mean IMT at common carotid arteries. At the stepwise multiple regression, the variables most significantly related to IMT in GH-deficient patients were total cholesterol levels (t = 5.2, P <0.001), followed by disease duration (t = 2.4, P = 0.02), while in controls the variables most significantly related to IMT were IGF-1 levels (t = -9.9, P <0.001), followed by low density lipoprotein (LDL)-cholesterol levels (t = -2.3, P = 0.02). Compared to patients with normal IGF-1 levels, those with low IGF-1 levels had lower high density lipoprotein (HDL)-cholesterol levels (1.0 ± 0.2 vs. 1.3 ± 0.2 mmol/l, P = 0.0002), and higher glucose (54.3 ± 6.1 vs. 48.9 ± 5.9 mmol/l, P = 0.008), insulin (25.2 ± 6.8 vs. 18.8 ± 6.0 mUl/l, P = 0.004), total cholesterol (7.1 ± 1.1 vs. 4.9 ± 0.6 mmol/l, P <0.0001), total/HDL-cholesterol ratio (7.2 ± 1.8 vs. 3.9 ± 0.7, P <0.0001), fibrinogen levels (319.8 ± 56.9 vs. 241.8 ± 53.0 mg/dl, P <0.0001) and mean IMT at common carotid arteries (1.05 ± 0.25 vs. 0.69 ± 0.07 mm, P <0.0001). Atherosclerotic plaques were found only in GH-deficient patients with low IGF-1 levels. CONCLUSlONS: GH-deficient patients have alterations in lipid profile with an increase in the total/HDL-cholesterol ratio, which is an index of increased cardiovascular risk, but only patients with IGF-1 deficiency have increased IMT.

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