Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities. Conclusion: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.
|Journal||Acta Paediatrica, International Journal of Paediatrics|
|Publication status||Accepted/In press - 2016|
- Insulin-like growth factor 1
- Preterm infant
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health