Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development

Ann Hellström, David Ley, Ingrid Hansen-Pupp, Boubou Hallberg, Chatarina Löfqvist, Linda van Marter, Mirjam van Weissenbruch, Luca A. Ramenghi, Kathryn Beardsall, David Dunger, Anna Lena Hård, Lois E H Smith

Research output: Contribution to journalArticle

Abstract

Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities. Conclusion: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.

Original languageEnglish
JournalActa Paediatrica, International Journal of Paediatrics
DOIs
Publication statusAccepted/In press - 2016

Keywords

  • Development
  • Foetus
  • Insulin-like growth factor 1
  • Metabolism
  • Preterm infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development'. Together they form a unique fingerprint.

  • Cite this

    Hellström, A., Ley, D., Hansen-Pupp, I., Hallberg, B., Löfqvist, C., van Marter, L., van Weissenbruch, M., Ramenghi, L. A., Beardsall, K., Dunger, D., Hård, A. L., & Smith, L. E. H. (Accepted/In press). Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatrica, International Journal of Paediatrics. https://doi.org/10.1111/apa.13350