Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development

Ann Hellström, David Ley, Ingrid Hansen-Pupp, Boubou Hallberg, Chatarina Löfqvist, Linda van Marter, Mirjam van Weissenbruch, Luca Antonio Ramenghi, Kathryn Beardsall, David Dunger, Anna Lena Hård, Lois E H Smith

Research output: Contribution to journalReview article

Abstract

UNLABELLED: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.

CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.

Original languageEnglish
Pages (from-to)576-586
Number of pages11
JournalActa Paediatrica, International Journal of Paediatrics
Volume105
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

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Somatomedins
Child Development
Premature Infants
Premature Birth
Growth
Morbidity
Fetal Development
Clinical Trials

Keywords

  • Development
  • Foetus
  • Insulin-like growth factor 1
  • Metabolism
  • Preterm infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Hellström, A., Ley, D., Hansen-Pupp, I., Hallberg, B., Löfqvist, C., van Marter, L., ... Smith, L. E. H. (2016). Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatrica, International Journal of Paediatrics, 105(6), 576-586. https://doi.org/10.1111/apa.13350

Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. / Hellström, Ann; Ley, David; Hansen-Pupp, Ingrid; Hallberg, Boubou; Löfqvist, Chatarina; van Marter, Linda; van Weissenbruch, Mirjam; Ramenghi, Luca Antonio; Beardsall, Kathryn; Dunger, David; Hård, Anna Lena; Smith, Lois E H.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 105, No. 6, 01.06.2016, p. 576-586.

Research output: Contribution to journalReview article

Hellström, A, Ley, D, Hansen-Pupp, I, Hallberg, B, Löfqvist, C, van Marter, L, van Weissenbruch, M, Ramenghi, LA, Beardsall, K, Dunger, D, Hård, AL & Smith, LEH 2016, 'Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development', Acta Paediatrica, International Journal of Paediatrics, vol. 105, no. 6, pp. 576-586. https://doi.org/10.1111/apa.13350
Hellström, Ann ; Ley, David ; Hansen-Pupp, Ingrid ; Hallberg, Boubou ; Löfqvist, Chatarina ; van Marter, Linda ; van Weissenbruch, Mirjam ; Ramenghi, Luca Antonio ; Beardsall, Kathryn ; Dunger, David ; Hård, Anna Lena ; Smith, Lois E H. / Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. In: Acta Paediatrica, International Journal of Paediatrics. 2016 ; Vol. 105, No. 6. pp. 576-586.
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