Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice

Bjarki Johannesson, Susanne Sattler, Ekaterina Semenova, Saveria Pastore, Teresa M. Kennedy-Lydon, Robert D. Sampson, Michael D. Schneider, Nadia Rosenthal, Daniel Bilbao

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Allergic contact dermatitis (ACD) is triggered by an aberrant hyperinflammatory immune response to innocuous chemical compounds and ranks as the world's most prevalent occupational skin condition. Although a variety of immune effector cells are activated during ACD, regulatory T (Treg) cells are crucial in controlling the resulting inflammation. Insulin-like growth factor-1 (IGF-1) regulates cell proliferation and differentiation and accelerates wound healing and regeneration in several organs including the skin. Recently IGF-1 has also been implicated in protection from autoimmune inflammation by expansion of Treg cells. Here, we demonstrate that ectopic expression of IGF-1 in mouse skin suppresses ACD in a Treg cell-specific manner, increasing the number of Foxp3+ Treg cells in the affected area and stimulating lymphocyte production of the anti-inflammatory cytokine interleukin 10. Similar therapeutic effects can be achieved with systemic or topical delivery of IGF-1, implicating this growth factor as a promising new therapeutic option for the treatment of ACD.

Original languageEnglish
Pages (from-to)977-985
Number of pages9
JournalDMM Disease Models and Mechanisms
Volume7
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Dermatitis
Allergic Contact Dermatitis
T-cells
Somatomedins
Regulatory T-Lymphocytes
Skin
Chemical compounds
Lymphocytes
Cell proliferation
Inflammation
Interleukin-10
Therapeutic Uses
Intercellular Signaling Peptides and Proteins
Anti-Inflammatory Agents
Wound Healing
Cytokines
Regeneration
Cell Differentiation
Cell Proliferation

Keywords

  • Atopic dermatitis
  • Contact hypersensitivity
  • Insulin-like growth factor-1
  • Regulatory T cells
  • Treg

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine (miscellaneous)
  • Immunology and Microbiology (miscellaneous)
  • Neuroscience (miscellaneous)
  • Medicine(all)

Cite this

Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice. / Johannesson, Bjarki; Sattler, Susanne; Semenova, Ekaterina; Pastore, Saveria; Kennedy-Lydon, Teresa M.; Sampson, Robert D.; Schneider, Michael D.; Rosenthal, Nadia; Bilbao, Daniel.

In: DMM Disease Models and Mechanisms, Vol. 7, No. 8, 2014, p. 977-985.

Research output: Contribution to journalArticle

Johannesson, B, Sattler, S, Semenova, E, Pastore, S, Kennedy-Lydon, TM, Sampson, RD, Schneider, MD, Rosenthal, N & Bilbao, D 2014, 'Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice', DMM Disease Models and Mechanisms, vol. 7, no. 8, pp. 977-985. https://doi.org/10.1242/dmm.015362
Johannesson, Bjarki ; Sattler, Susanne ; Semenova, Ekaterina ; Pastore, Saveria ; Kennedy-Lydon, Teresa M. ; Sampson, Robert D. ; Schneider, Michael D. ; Rosenthal, Nadia ; Bilbao, Daniel. / Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice. In: DMM Disease Models and Mechanisms. 2014 ; Vol. 7, No. 8. pp. 977-985.
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