Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice

Bjarki Johannesson, Susanne Sattler, Ekaterina Semenova, Saveria Pastore, Teresa M. Kennedy-Lydon, Robert D. Sampson, Michael D. Schneider, Nadia Rosenthal, Daniel Bilbao

Research output: Contribution to journalArticlepeer-review

Abstract

Allergic contact dermatitis (ACD) is triggered by an aberrant hyperinflammatory immune response to innocuous chemical compounds and ranks as the world's most prevalent occupational skin condition. Although a variety of immune effector cells are activated during ACD, regulatory T (Treg) cells are crucial in controlling the resulting inflammation. Insulin-like growth factor-1 (IGF-1) regulates cell proliferation and differentiation and accelerates wound healing and regeneration in several organs including the skin. Recently IGF-1 has also been implicated in protection from autoimmune inflammation by expansion of Treg cells. Here, we demonstrate that ectopic expression of IGF-1 in mouse skin suppresses ACD in a Treg cell-specific manner, increasing the number of Foxp3+ Treg cells in the affected area and stimulating lymphocyte production of the anti-inflammatory cytokine interleukin 10. Similar therapeutic effects can be achieved with systemic or topical delivery of IGF-1, implicating this growth factor as a promising new therapeutic option for the treatment of ACD.

Original languageEnglish
Pages (from-to)977-985
Number of pages9
JournalDMM Disease Models and Mechanisms
Volume7
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • Atopic dermatitis
  • Contact hypersensitivity
  • Insulin-like growth factor-1
  • Regulatory T cells
  • Treg

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine (miscellaneous)
  • Immunology and Microbiology (miscellaneous)
  • Neuroscience (miscellaneous)
  • Medicine(all)

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