Insulin-like growth factor-1 is associated with bone formation markers, PTH and bone mineral density in healthy premenopausal women

Silvano Adami, Alessandra Zivelonghi, Vania Braga, Elena Fracassi, Davide Gatti, Maurizio Rossini, Fabio M. Ulivieri, Ombretta Viapiana

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Bone turnover markers (BTM) progressively decrease in young adult women. This might be linked to changes in insulin-like growth factor-1 (IGF-I). Four serum BTMs [serum C-telopeptide of type 1 collagen (CTX), osteocalcin (OC), N-terminal propeptide of type 1 procollagen (P1NP), and bone alkaline phosphatase (bone AP)], serum calcium (sCa), phosphate (sPO4), magnesium, 25-hydroxyvitamin D [25(OH)D], intact parathyroid hormone (PTH) and IGF-I were measured in 531 young healthy premenopausal women aged 20-50 years participating in the BONTURNO study. In all subjects bone mineral density (BMD) was measured at the spine and at the hip by dual-energy X-ray densitometry. Hip BMD, IGF-I, the four BTMs, sCa and sPO4 progressively decreased with advancing age and this was associated with proportional increases in PTH. IGF-I levels were significantly and positively correlated with sCa, sPO4, CTX, OC, P1NP, bone AP, spine BMD, femoral neck BMD and total hip BMD and negatively with age, BMI and serum PTH. When the IGF-I levels were adjusted for age and BMI, the only correlations maintaining a statistical significance were those with serum PTH, P1NP and bone AP. These associations were weak and IGF-I accounted for a only a small proportion of the BTM variance. The mean, age-adjusted IGF-I values were significantly higher in women practicing physical exercises for more then 60 min per week than in sedentary women. In conclusion, in this study we provide evidence of an association between the age-related decline in IGF-I with the progressive decrease in bone formation markers in premenopausal women.

Original languageEnglish
Pages (from-to)244-247
Number of pages4
JournalBone
Volume46
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Somatomedins
Parathyroid Hormone
Insulin-Like Growth Factor I
Osteogenesis
Bone Density
Serum
Pelvic Bones
Alkaline Phosphatase
Bone Remodeling
Osteocalcin
Collagen Type I
Bone and Bones
Spine
Calcium
Femur Neck
Photon Absorptiometry
Hip
Young Adult
Exercise

Keywords

  • Bone mineral density
  • Bone turnover markers
  • IGF-I
  • Physical activity
  • Premenopausal women
  • PTH

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

Adami, S., Zivelonghi, A., Braga, V., Fracassi, E., Gatti, D., Rossini, M., ... Viapiana, O. (2010). Insulin-like growth factor-1 is associated with bone formation markers, PTH and bone mineral density in healthy premenopausal women. Bone, 46(1), 244-247. https://doi.org/10.1016/j.bone.2009.10.011

Insulin-like growth factor-1 is associated with bone formation markers, PTH and bone mineral density in healthy premenopausal women. / Adami, Silvano; Zivelonghi, Alessandra; Braga, Vania; Fracassi, Elena; Gatti, Davide; Rossini, Maurizio; Ulivieri, Fabio M.; Viapiana, Ombretta.

In: Bone, Vol. 46, No. 1, 01.2010, p. 244-247.

Research output: Contribution to journalArticle

Adami, Silvano ; Zivelonghi, Alessandra ; Braga, Vania ; Fracassi, Elena ; Gatti, Davide ; Rossini, Maurizio ; Ulivieri, Fabio M. ; Viapiana, Ombretta. / Insulin-like growth factor-1 is associated with bone formation markers, PTH and bone mineral density in healthy premenopausal women. In: Bone. 2010 ; Vol. 46, No. 1. pp. 244-247.
@article{318ff61e5b6c4a1f98c556e2174ad2c5,
title = "Insulin-like growth factor-1 is associated with bone formation markers, PTH and bone mineral density in healthy premenopausal women",
abstract = "Bone turnover markers (BTM) progressively decrease in young adult women. This might be linked to changes in insulin-like growth factor-1 (IGF-I). Four serum BTMs [serum C-telopeptide of type 1 collagen (CTX), osteocalcin (OC), N-terminal propeptide of type 1 procollagen (P1NP), and bone alkaline phosphatase (bone AP)], serum calcium (sCa), phosphate (sPO4), magnesium, 25-hydroxyvitamin D [25(OH)D], intact parathyroid hormone (PTH) and IGF-I were measured in 531 young healthy premenopausal women aged 20-50 years participating in the BONTURNO study. In all subjects bone mineral density (BMD) was measured at the spine and at the hip by dual-energy X-ray densitometry. Hip BMD, IGF-I, the four BTMs, sCa and sPO4 progressively decreased with advancing age and this was associated with proportional increases in PTH. IGF-I levels were significantly and positively correlated with sCa, sPO4, CTX, OC, P1NP, bone AP, spine BMD, femoral neck BMD and total hip BMD and negatively with age, BMI and serum PTH. When the IGF-I levels were adjusted for age and BMI, the only correlations maintaining a statistical significance were those with serum PTH, P1NP and bone AP. These associations were weak and IGF-I accounted for a only a small proportion of the BTM variance. The mean, age-adjusted IGF-I values were significantly higher in women practicing physical exercises for more then 60 min per week than in sedentary women. In conclusion, in this study we provide evidence of an association between the age-related decline in IGF-I with the progressive decrease in bone formation markers in premenopausal women.",
keywords = "Bone mineral density, Bone turnover markers, IGF-I, Physical activity, Premenopausal women, PTH",
author = "Silvano Adami and Alessandra Zivelonghi and Vania Braga and Elena Fracassi and Davide Gatti and Maurizio Rossini and Ulivieri, {Fabio M.} and Ombretta Viapiana",
year = "2010",
month = "1",
doi = "10.1016/j.bone.2009.10.011",
language = "English",
volume = "46",
pages = "244--247",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Insulin-like growth factor-1 is associated with bone formation markers, PTH and bone mineral density in healthy premenopausal women

AU - Adami, Silvano

AU - Zivelonghi, Alessandra

AU - Braga, Vania

AU - Fracassi, Elena

AU - Gatti, Davide

AU - Rossini, Maurizio

AU - Ulivieri, Fabio M.

AU - Viapiana, Ombretta

PY - 2010/1

Y1 - 2010/1

N2 - Bone turnover markers (BTM) progressively decrease in young adult women. This might be linked to changes in insulin-like growth factor-1 (IGF-I). Four serum BTMs [serum C-telopeptide of type 1 collagen (CTX), osteocalcin (OC), N-terminal propeptide of type 1 procollagen (P1NP), and bone alkaline phosphatase (bone AP)], serum calcium (sCa), phosphate (sPO4), magnesium, 25-hydroxyvitamin D [25(OH)D], intact parathyroid hormone (PTH) and IGF-I were measured in 531 young healthy premenopausal women aged 20-50 years participating in the BONTURNO study. In all subjects bone mineral density (BMD) was measured at the spine and at the hip by dual-energy X-ray densitometry. Hip BMD, IGF-I, the four BTMs, sCa and sPO4 progressively decreased with advancing age and this was associated with proportional increases in PTH. IGF-I levels were significantly and positively correlated with sCa, sPO4, CTX, OC, P1NP, bone AP, spine BMD, femoral neck BMD and total hip BMD and negatively with age, BMI and serum PTH. When the IGF-I levels were adjusted for age and BMI, the only correlations maintaining a statistical significance were those with serum PTH, P1NP and bone AP. These associations were weak and IGF-I accounted for a only a small proportion of the BTM variance. The mean, age-adjusted IGF-I values were significantly higher in women practicing physical exercises for more then 60 min per week than in sedentary women. In conclusion, in this study we provide evidence of an association between the age-related decline in IGF-I with the progressive decrease in bone formation markers in premenopausal women.

AB - Bone turnover markers (BTM) progressively decrease in young adult women. This might be linked to changes in insulin-like growth factor-1 (IGF-I). Four serum BTMs [serum C-telopeptide of type 1 collagen (CTX), osteocalcin (OC), N-terminal propeptide of type 1 procollagen (P1NP), and bone alkaline phosphatase (bone AP)], serum calcium (sCa), phosphate (sPO4), magnesium, 25-hydroxyvitamin D [25(OH)D], intact parathyroid hormone (PTH) and IGF-I were measured in 531 young healthy premenopausal women aged 20-50 years participating in the BONTURNO study. In all subjects bone mineral density (BMD) was measured at the spine and at the hip by dual-energy X-ray densitometry. Hip BMD, IGF-I, the four BTMs, sCa and sPO4 progressively decreased with advancing age and this was associated with proportional increases in PTH. IGF-I levels were significantly and positively correlated with sCa, sPO4, CTX, OC, P1NP, bone AP, spine BMD, femoral neck BMD and total hip BMD and negatively with age, BMI and serum PTH. When the IGF-I levels were adjusted for age and BMI, the only correlations maintaining a statistical significance were those with serum PTH, P1NP and bone AP. These associations were weak and IGF-I accounted for a only a small proportion of the BTM variance. The mean, age-adjusted IGF-I values were significantly higher in women practicing physical exercises for more then 60 min per week than in sedentary women. In conclusion, in this study we provide evidence of an association between the age-related decline in IGF-I with the progressive decrease in bone formation markers in premenopausal women.

KW - Bone mineral density

KW - Bone turnover markers

KW - IGF-I

KW - Physical activity

KW - Premenopausal women

KW - PTH

UR - http://www.scopus.com/inward/record.url?scp=72049084791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72049084791&partnerID=8YFLogxK

U2 - 10.1016/j.bone.2009.10.011

DO - 10.1016/j.bone.2009.10.011

M3 - Article

VL - 46

SP - 244

EP - 247

JO - Bone

JF - Bone

SN - 8756-3282

IS - 1

ER -