Insulin-like growth factor-1 receptor and phosphorylated AKT-serine 473 expression in 132 resected thymomas and thymic carcinomas

Paolo A. Zucali, Iacopo Petrini, Elena Lorenzi, Maria Merino, Liang Cao, Luca Di Tommaso, Hye Seung Lee, Matteo Incarbone, Beatriz A. Walter, Matteo Simonelli, Massimo Roncalli, Armando Santoro, Giuseppe Giaccone

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Thymic malignancies are rare tumors. The insulin-like growth factor-1 (IGF-1)/IGF-1 receptor (IGF-1R) system is involved in the development of the thymus. IGF-1R expression in thymic epithelial malignancies is unknown. METHODS: The authors investigated the expression of IGF-1R and phosphorylated AKT serine 473 (p-AKT) by using immunohistochemistry and examined the clinicopathologic correlations in a retrospective, single-institution surgical series of 132 patients with thymic epithelial malignancies. RESULTS: Earlier disease stage, less aggressive histologic types, and complete resection were significant positive prognostic factors for disease-related survival and progression-free survival, and being a woman was a better prognostic factor for disease-related survival. IGF-1R and p-AKT protein levels were expressed in 20% and 36% of thymic tumors, respectively. Both markers were expressed more commonly in recurrent disease than in primary tumors, in more aggressive subtypes, and in more advanced disease stages. There was a trend toward better survival and progression-free survival in patients who were negative for IGF-1R or p-AKT expression in the whole series. When only the 91 primary tumors, IGF1R expression was associated with worse progression-free survival (P

Original languageEnglish
Pages (from-to)4686-4695
Number of pages10
JournalCancer
Volume116
Issue number20
DOIs
Publication statusPublished - 2010

Keywords

  • Expression
  • Immunohistochemistry
  • Insulin-like growth factor-1 receptor
  • Prognosis
  • Thymoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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