Insulin-like growth factor 1 receptor expression in wild-type GISTs: A potential novel therapeutic target

Maria A. Pantaleo, Annalisa Astolfi, Monica Di Battista, Michael C. Heinrich, Paola Paterini, Katia Scotlandi, Donatella Santini, Fausto Catena, Maria C. Manara, Margherita Nannini, Alessandra Maleddu, Maristella Saponara, Cristian Lolli, Serena Formica, Guido Biasco

Research output: Contribution to journalArticle

Abstract

Aberrations of the Insulin-like Growth Factor (IGF) system have been found in association with a variety of cancer types. The potential role of IGF1R has been postulated in a small subset of GISTs, but until now the implications of its aberrations have not been defined. The aim of the study was to examine the IGF1R status in patients with gastric GIST in regard to KIT and PDGFRA genotype. Fresh resection specimens were collected from 8 primary tumours [2 wild-type (WT) and 6 mutant cases]. IGF1R was studied as gene expression profiling with Affymetrix GeneChip HG-U133Plus 2.0 arrays and as genomic copy number with SNP array analysis Affymetrix Genome Wide Human SNP 6.0 arrays, and at protein level with western blotting (WB) and immunohistochemistry (IHC). The unsupervised analysis of gene expression profiling of our patients merged with a data set from gastric GISTs identified 2 patients out of 8 with different expression of IGF1R. The data were confirmed by WB and IHC. In particular, IGF1R was upregulated in 2 young patients (

Original languageEnglish
Pages (from-to)2991-2994
Number of pages4
JournalInternational Journal of Cancer
Volume125
Issue number12
DOIs
Publication statusPublished - Dec 15 2009

Keywords

  • Gastrointestinal stromal tumours
  • Insulin-like growth factor 1 receptor
  • KIT receptor
  • PDGFRA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Pantaleo, M. A., Astolfi, A., Di Battista, M., Heinrich, M. C., Paterini, P., Scotlandi, K., Santini, D., Catena, F., Manara, M. C., Nannini, M., Maleddu, A., Saponara, M., Lolli, C., Formica, S., & Biasco, G. (2009). Insulin-like growth factor 1 receptor expression in wild-type GISTs: A potential novel therapeutic target. International Journal of Cancer, 125(12), 2991-2994. https://doi.org/10.1002/ijc.24595