Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva--TRELONG).

Diego Albani, Stefano Mazzuco, Letizia Polito, Sara Batelli, Gloria Biella, Fausta Ongaro, Deborah R. Gustafson, Piero Antuono, Gianbattista Gajo, Elisabetta Durante, Livio Caberlotto, Andrea Zanardo, Marinella Siculi, Maurizio Gallucci, Gianluigi Forloni

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Abstract

Insulin-like growth factor 1 (IGF-1) signaling modulation has been associated with increased lifespan in model organisms, while high levels of circulating interleukin-6 (IL-6) are a marker of disability and mortality. In the prospective, population-based "Treviso Longeva"--TRELONG Study from Italy (n = 668, age range 70-105.5 years at baseline, followed for seven years) we investigated the effects of survival on the IGF-1 receptor (IGF-1R) gene polymorphism rs2229765, the IL-6 gene promoter polymorphism rs1800795, and plasma concentrations of IGF-1 and IL-6, alone or in combination. We found a sex-dependent effect for the IGF-1R rs2229765 polymorphism, as male carriers of the homozygous A/A genotype survived longer, while the IL-6 rs1800795 genotype did not influence overall or sex-specific longevity. Higher IL-6 levels were more detrimental for survival among males than females, while IGF-1 had no dose-response effect. These findings sustain the hypothesis that sex-specific longevity relies on detectable differences in genetic and biochemical parameters between males and females.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalAging Male
Volume14
Issue number4
Publication statusPublished - Dec 2011

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Somatomedin Receptors
Interleukin-6
Prospective Studies
Somatomedins
Population
Genotype
IGF Type 1 Receptor
Italy
Genes
Molecular Biology
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva--TRELONG). / Albani, Diego; Mazzuco, Stefano; Polito, Letizia; Batelli, Sara; Biella, Gloria; Ongaro, Fausta; Gustafson, Deborah R.; Antuono, Piero; Gajo, Gianbattista; Durante, Elisabetta; Caberlotto, Livio; Zanardo, Andrea; Siculi, Marinella; Gallucci, Maurizio; Forloni, Gianluigi.

In: Aging Male, Vol. 14, No. 4, 12.2011, p. 257-264.

Research output: Contribution to journalArticle

Albani, D, Mazzuco, S, Polito, L, Batelli, S, Biella, G, Ongaro, F, Gustafson, DR, Antuono, P, Gajo, G, Durante, E, Caberlotto, L, Zanardo, A, Siculi, M, Gallucci, M & Forloni, G 2011, 'Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva--TRELONG).', Aging Male, vol. 14, no. 4, pp. 257-264.
Albani, Diego ; Mazzuco, Stefano ; Polito, Letizia ; Batelli, Sara ; Biella, Gloria ; Ongaro, Fausta ; Gustafson, Deborah R. ; Antuono, Piero ; Gajo, Gianbattista ; Durante, Elisabetta ; Caberlotto, Livio ; Zanardo, Andrea ; Siculi, Marinella ; Gallucci, Maurizio ; Forloni, Gianluigi. / Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva--TRELONG). In: Aging Male. 2011 ; Vol. 14, No. 4. pp. 257-264.
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