Insulin-like growth factor-1 signaling in renal cell carcinoma

Adam F. Tracz, Cezary Szczylik, Camillo Porta, Anna M. Czarnecka

Research output: Contribution to journalArticle

Abstract

Renal cell carcinoma (RCC) incidence is highest in highly developed countries and it is the seventh most common neoplasm diagnosed. RCC management include nephrectomy and targeted therapies. Type 1 insulin-like growth factor (IGF-1) pathway plays an important role in cell proliferation and apoptosis resistance. IGF-1 and insulin share overlapping downstream signaling pathways in normal and cancer cells. IGF-1 receptor (IGF1R) stimulation may promote malignant transformation promoting cell proliferation, dedifferentiation and inhibiting apoptosis. Clear cell renal cell carcinoma (ccRCC) patients with IGF1R overexpression have 70 % increased risk of death compared to patients who had tumors without IGF1R expression. IGF1R signaling deregulation may results in p53, WT, BRCA1, VHL loss of function. RCC cells with high expression of IGF1R are more resistant to chemotherapy than cells with low expression. Silencing of IGF1R increase the chemosensitivity of ccRCC cells and the effect is greater in VHL mutated cells. Understanding the role of IGF-1 signaling pathway in RCC may result in development of new targeted therapeutic interventions. First preclinical attempts with anti-IGF-1R monoclonal antibodies or fragment antigen-binding (Fab) fragments alone or in combination with an mTOR inhibitor were shown to inhibit in vitro growth and reduced the number of colonies formed by of RCC cells.

Original languageEnglish
Article number453
JournalBMC Cancer
Volume16
Issue number1
DOIs
Publication statusPublished - Jul 12 2016

Keywords

  • CcRCC)
  • IGF-1 receptor (IGF1R)
  • Insulin-like growth factor-1 (IGF-1)
  • Renal cell carcinoma (RCC

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

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