Trattamento della nefrotossicita da farmaci immunosoppressori con insulin-like growth factor-I

Translated title of the contribution: Insulin-like growth factor ameliorates the renal toxicity of mainstream immunosuppressant

M. Maestri, P. Dionigi, P. Pettenazza, F. Visconti, J. Rademacher, A. Gaspari, F. Innocente, C. Matteotti, F. Luzzana, A. Zonta

Research output: Contribution to journalArticle

Abstract

Background. Delayed graft function is a common and severe complication after cadaveric kidney transplantation. Besides a more complicated postoperative course, DGF can worsen the overall graft survival. In particular, DGF enhances the nephrotoxicity of mainstream immunosuppressants cyclosporine and FK506. This study evaluates a new therapeutical approach to the treatment of DGF related nephrotoxicity, based on the administration of IGF-I. Methods. Sixty inbred Lewis rats underwent a bilateral clamping of the renal pedicles (20') as standard damage. The animals were stratified in six groups, according to the postoperative treatment. Group 1 served as control and received only the standard ischemic injury. Cyclosporine and FK506 were added in groups 3 and 5. Groups 2, 4 and 6 had the same treatment of groups 1, 3, 5 respectively, plus the administration of IGF-I. Blood samples were drawn daily to evaluate creatinine and BUN for 7 days. Results. The rats treated with IGF-I had significantly better values compared to the respective controls (2-way ANOVA, p <0.05). Conclusions. In conclusion, IGF-I improves the nephrotoxicity of mainstream immunosuppressants in this model. Its use is potentially beneficial for transplantation.

Translated title of the contributionInsulin-like growth factor ameliorates the renal toxicity of mainstream immunosuppressant
Original languageItalian
Pages (from-to)391-396
Number of pages6
JournalMinerva Chirurgica
Volume53
Issue number5
Publication statusPublished - May 1998

ASJC Scopus subject areas

  • Surgery

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    Maestri, M., Dionigi, P., Pettenazza, P., Visconti, F., Rademacher, J., Gaspari, A., Innocente, F., Matteotti, C., Luzzana, F., & Zonta, A. (1998). Trattamento della nefrotossicita da farmaci immunosoppressori con insulin-like growth factor-I. Minerva Chirurgica, 53(5), 391-396.