TY - JOUR
T1 - Insulin-like growth factor binding protein 1 (IGFBP-1) levels in Turner syndrome
AU - Cianfarani, S.
AU - Holly, J. M P
AU - Pasquino, A. M.
AU - Vaccaro, F.
AU - Spadoni, G. L.
AU - Bernardini, S.
AU - Segni, M.
AU - Boscherini, B.
PY - 1992
Y1 - 1992
N2 - We tested whether IGFBP-1, a modulator of IGF-I action, would play a role in the pathogenesis of growth failure and metabolic picture of Turner syndrome. Fasting serum levels of IGFBP-1 were assessed in nineteen girls with Turner syndrome (aging 6.5 to 17.2 years) by radioimmunoassay. Our patients showed normal values of IGFBP-1 (mean ± SD: 68.6 ± 32.5 μg/l, range: 16 to 134 μg/l; range for age and pubertal stage-matched normal children: 15 to 180 μg/l). IGFBP-1 levels inversely correlated with bone age (p <0.05), weight (p <0.001), percentage of ideal body weight (p <0.002) and body mass index (BMI) (p <0.001). Our results seem to rule out a role of IGFBP-1 in the pathogenesis of growth failure in Turner syndrome. The close inverse relationship between IGFBP-1 levels and BMI suggests the serum concentrations of IGFBP-1 to be regulated by the nutritional status. Due to IGFBP-1 inhibiting action on IGF biological activity, the reduction of IGFBP-1 levels in overweight subjects might represent a mechanism to enhance the IGF insulin-like activity, thus supplementing the insulin action.
AB - We tested whether IGFBP-1, a modulator of IGF-I action, would play a role in the pathogenesis of growth failure and metabolic picture of Turner syndrome. Fasting serum levels of IGFBP-1 were assessed in nineteen girls with Turner syndrome (aging 6.5 to 17.2 years) by radioimmunoassay. Our patients showed normal values of IGFBP-1 (mean ± SD: 68.6 ± 32.5 μg/l, range: 16 to 134 μg/l; range for age and pubertal stage-matched normal children: 15 to 180 μg/l). IGFBP-1 levels inversely correlated with bone age (p <0.05), weight (p <0.001), percentage of ideal body weight (p <0.002) and body mass index (BMI) (p <0.001). Our results seem to rule out a role of IGFBP-1 in the pathogenesis of growth failure in Turner syndrome. The close inverse relationship between IGFBP-1 levels and BMI suggests the serum concentrations of IGFBP-1 to be regulated by the nutritional status. Due to IGFBP-1 inhibiting action on IGF biological activity, the reduction of IGFBP-1 levels in overweight subjects might represent a mechanism to enhance the IGF insulin-like activity, thus supplementing the insulin action.
KW - IGFBP-1
KW - Insulin-like growth factor
KW - Insulin-like growth factor binding protein
KW - Turner syndrome
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M3 - Article
C2 - 1280613
AN - SCOPUS:0026448518
VL - 24
SP - 537
EP - 540
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 11
ER -