Insulin-like growth factor-I ameliorates delayed kidney graft function and the acute nephrotoxic effects of cyclosporine

Marcello Maestri, Donald C. Dafoe, Greeg A. Adams, Annalisa Gaspari, Francesco Luzzana, Francesco Innocente, Johannes Rademacher, Paolo Dionigi, Annalisa Barbieri, Franco Zonta, Aris Zonta, Ralph Rabkin

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Background. Delayed graft function (DGF) is a relatively common complication after cadaveric renal transplantation. The adverse effect of DGF on long-term graft survival has lead to intensive efforts to reduce ischemic graft injury. In this study we examined the effects of a new protective treatment based on insulin growth factor (IGF)-I. We evaluated the impact of the treatment on renal recovery and on the nephrotoxicity that is a common side effect of mainstream immunosuppressants. Because therapy with IGF-I or the analog des(1-3)IGF-I is effective in treating experimental ischemic renal failure, these peptides may be useful as perspective clinical treatments. Methods. We have addressed three areas relating to the potential use of IGF- I and its analog des(1-3)IGF-I. First, because of the immunogenic properties of IGF-I, we assessed the effect of des(1-3)IGF-I on the rejection of skin allografts in Lewis rats. Next we determined whether treatment with des(1- 3)IGF-I influences the early function of transplanted kidneys in a model of DGF induced by a combination of warm and cold ischemia. Finally we tested whether IGF-I protects against acute cyclosporine nephrotoxicity. Results. Des(1-3)IGF-I did not accelerate the rejection of the skin grafts (P=0.57). The administration of this peptide in a model of syngenic renal transplant improved the early function of the graft. Postoperative values of creatinine and blood urea nitrogen were significantly better (P

Original languageEnglish
Pages (from-to)185-190
Number of pages6
Issue number2
Publication statusPublished - Jul 27 1997

ASJC Scopus subject areas

  • Transplantation
  • Immunology


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