Insulin-like growth factor-I expression in normal and diseased endometrium

Eugenio Maiorano, Giuseppe Loverro, Giuseppe Viale, Teresa Giannini, Anna Napoli, Elda Perlino

Research output: Contribution to journalArticlepeer-review

Abstract

While the role of steroid hormones in the regulation of endometrial proliferation and differentiation is well established, the effects of growth factors and their receptors in normal and neoplastic endometrium remain a matter of debate. Previous studies have documented the positive effects of insulin-like growth factor-I (IGF-I) on epithelial cell proliferation and the active production of this growth factor in endometrial tissues. In view of decreased expression of transforming growth factor-β1 (TGF-β1), an antagonist of IGF-I, in endometrial carcinoma, we investigated the expression of IGF-I, at both the mRNA and protein levels, and the immunoreactivity for type I IGF-I receptor in 30 formalin-fixed, paraffin-embedded tissue samples of normal and neoplastic endometrium, in order to possibly clarify the role of IGF-I in endometrial proliferation and differentiation. Our results demonstrate a reduced expression of IGF-I mRNA in endometrial carcinomas compared with non-neoplastic tissues, despite equivalent immunohistochemical expression of IGF-I and IGF-I receptor. Our data suggest that IGF-I and its corresponding receptor may not be directly involved in endometrial cancer cell proliferation and differentiation in vivo, though other components of the IGF-I system (e.g., IGF binding proteins) may affect endometrial malignant transformation and tumor progression.

Original languageEnglish
Pages (from-to)188-193
Number of pages6
JournalInternational Journal of Cancer
Volume80
Issue number2
DOIs
Publication statusPublished - Jan 18 1999

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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