Abstract
Insulin-like growth factor 1 (IGF-1) likely is involved in thyrocyte proliferation via autocrine mechanisms, but limited data are available on its in vivo expression in thyroid neoplasms. This prompted us to explore IGF-1 expression at the protein and mRNA levels and IGF-1 receptor (IGF-1rec) immunore-activity in normal and neoplastic thyroids (50 adenomas and 53 carcinomas). We documented increased IGF-1 and IGF-1rec immunoreactivity in adenomas (31 of 50 and 40 of 50 cases, respectively) and carcinomas (38 of 53 and 42 of 53 cases) compared with normal thyroid, which only showed minimal immunoreactivity for the ligand and its receptor. A corresponding up- regulation of IGF-1 mRNA was documented in carcinomas, whereas adenomas exhibited down-regulated expression of IGF-1 mRNA. Immunoreactivity for IGF-1 and cognate receptor positively correlated with tumor diameter and wide intrathyroidal extension but not with patients' gender and age or with the stage of the tumors and the occurrence of lymph node metastases. These data emphasize a possible role of the IGF-1 system in thyroid tumorigenesis, as indicated by in vitro studies. In addition, the evaluation of IGF-1 and IGF- 1rec immunoreactivity might have clinical implications, because it positively correlates with the aggressiveness of these tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 110-119 |
| Number of pages | 10 |
| Journal | Applied Immunohistochemistry and Molecular Morphology |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2000 |
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Keywords
- Growth factors
- Insulin-like growth factor
- Insulin-like growth factor receptor
- Thyroid gland
- Thyroid neoplasms
ASJC Scopus subject areas
- Anatomy
- Medical Laboratory Technology
Cite this
Insulin-like growth factor I expression in thyroid tumors. / Maiorano, Eugenio; Ciampolillo, Anna; Viale, Giuseppe; Maisonneuve, Patrick; Ambrosi, Antonio; Triggiani, Vincenzo; Marra, Ersilia; Perlino, Elda.
In: Applied Immunohistochemistry and Molecular Morphology, Vol. 8, No. 2, 06.2000, p. 110-119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin-like growth factor I expression in thyroid tumors
AU - Maiorano, Eugenio
AU - Ciampolillo, Anna
AU - Viale, Giuseppe
AU - Maisonneuve, Patrick
AU - Ambrosi, Antonio
AU - Triggiani, Vincenzo
AU - Marra, Ersilia
AU - Perlino, Elda
PY - 2000/6
Y1 - 2000/6
N2 - Insulin-like growth factor 1 (IGF-1) likely is involved in thyrocyte proliferation via autocrine mechanisms, but limited data are available on its in vivo expression in thyroid neoplasms. This prompted us to explore IGF-1 expression at the protein and mRNA levels and IGF-1 receptor (IGF-1rec) immunore-activity in normal and neoplastic thyroids (50 adenomas and 53 carcinomas). We documented increased IGF-1 and IGF-1rec immunoreactivity in adenomas (31 of 50 and 40 of 50 cases, respectively) and carcinomas (38 of 53 and 42 of 53 cases) compared with normal thyroid, which only showed minimal immunoreactivity for the ligand and its receptor. A corresponding up- regulation of IGF-1 mRNA was documented in carcinomas, whereas adenomas exhibited down-regulated expression of IGF-1 mRNA. Immunoreactivity for IGF-1 and cognate receptor positively correlated with tumor diameter and wide intrathyroidal extension but not with patients' gender and age or with the stage of the tumors and the occurrence of lymph node metastases. These data emphasize a possible role of the IGF-1 system in thyroid tumorigenesis, as indicated by in vitro studies. In addition, the evaluation of IGF-1 and IGF- 1rec immunoreactivity might have clinical implications, because it positively correlates with the aggressiveness of these tumors.
AB - Insulin-like growth factor 1 (IGF-1) likely is involved in thyrocyte proliferation via autocrine mechanisms, but limited data are available on its in vivo expression in thyroid neoplasms. This prompted us to explore IGF-1 expression at the protein and mRNA levels and IGF-1 receptor (IGF-1rec) immunore-activity in normal and neoplastic thyroids (50 adenomas and 53 carcinomas). We documented increased IGF-1 and IGF-1rec immunoreactivity in adenomas (31 of 50 and 40 of 50 cases, respectively) and carcinomas (38 of 53 and 42 of 53 cases) compared with normal thyroid, which only showed minimal immunoreactivity for the ligand and its receptor. A corresponding up- regulation of IGF-1 mRNA was documented in carcinomas, whereas adenomas exhibited down-regulated expression of IGF-1 mRNA. Immunoreactivity for IGF-1 and cognate receptor positively correlated with tumor diameter and wide intrathyroidal extension but not with patients' gender and age or with the stage of the tumors and the occurrence of lymph node metastases. These data emphasize a possible role of the IGF-1 system in thyroid tumorigenesis, as indicated by in vitro studies. In addition, the evaluation of IGF-1 and IGF- 1rec immunoreactivity might have clinical implications, because it positively correlates with the aggressiveness of these tumors.
KW - Growth factors
KW - Insulin-like growth factor
KW - Insulin-like growth factor receptor
KW - Thyroid gland
KW - Thyroid neoplasms
UR - http://www.scopus.com/inward/record.url?scp=0033865463&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033865463&partnerID=8YFLogxK
U2 - 10.1097/00022744-200006000-00005
DO - 10.1097/00022744-200006000-00005
M3 - Article
VL - 8
SP - 110
EP - 119
JO - Applied Immunohistochemistry and Molecular Morphology
JF - Applied Immunohistochemistry and Molecular Morphology
SN - 1541-2016
IS - 2
ER -