Insulin-like growth factor (IGF)-I and IGF-binding protein-3 serum levels in relapsing-remitting and secondary progressive multiple sclerosis patients

R. Lanzillo, C. Di Somma, M. Quarantelli, G. Ventrella, M. Gasperi, A. Prinster, G. Vacca, C. Pivonello, G. Orefice, A. Colao, V. B. Morra

Research output: Contribution to journalArticle

Abstract

Background: Insulin-like growth factor (IGF)-I has a role in remyelination, and insulin-like growth factor-binding protein-3 (IGFBP-3) might reduce its bioavailability. A role of IGFBP-3 in multiple sclerosis (MS) progression was hypothesized in patients with primary progressive (PP) MS. Objective: To evaluate serum levels of IGF-I and IGFBP-3 in patients with relapsing-remitting (RR) and secondary progressive (SP) MS and their correlations with disease activity and progression. Methods: Sixty-three (41 RR and 22 SP) 'naive' MS patients and 60 age-matched healthy controls were enrolled. Patients were assessed through clinical [Expanded Disability Status Scale (EDSS), Multiple Sclerosis Severity Scale (MSSS), number of relapses] and laboratory investigations. IGF-I and IGFBP-3 were measured by ELISA. Results: Levels of IGF-I and IGFBP-3 were similar in the two MS groups. IGFBP-3 levels were higher in patients with MS than in controls (P

Original languageEnglish
Pages (from-to)1402-1406
Number of pages5
JournalEuropean Journal of Neurology
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 2011

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Keywords

  • Case-control study
  • Insulin-like growth factor-binding protein-3
  • Insulin-like growth factor-I
  • Multiple sclerosis
  • Relapsing-remitting
  • Secondary progressive

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Lanzillo, R., Di Somma, C., Quarantelli, M., Ventrella, G., Gasperi, M., Prinster, A., Vacca, G., Pivonello, C., Orefice, G., Colao, A., & Morra, V. B. (2011). Insulin-like growth factor (IGF)-I and IGF-binding protein-3 serum levels in relapsing-remitting and secondary progressive multiple sclerosis patients. European Journal of Neurology, 18(12), 1402-1406. https://doi.org/10.1111/j.1468-1331.2011.03433.x