Insulin-like growth factor-II: New roles for an old actor

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Insulin-like growth factor-II (IGF-II), traditionally considered as a growth factor implicated in growth of fetal tissues and cancer cells, is now emerging as a potential metabolic regulator. The aim of this overview is to provide the available evidence, obtained in both experimen- tal conditions and in humans, for a role of IGF-II in the fine-tuning of metabolism and body composition. The underlying mechanisms and the potential clinical implications are discussed.

Original languageEnglish
Article numberArticle 118
JournalFrontiers in Endocrinology
Issue numberOCT
Publication statusPublished - 2012


  • Body composition
  • Insulin
  • Insulin receptor
  • Insulin-like growth factor I
  • Insulin-like growth factor II

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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