Insulin-like growth factor-II (IGF-II), traditionally considered as a growth factor implicated in growth of fetal tissues and cancer cells, is now emerging as a potential metabolic regulator. The aim of this overview is to provide the available evidence, obtained in both experimen- tal conditions and in humans, for a role of IGF-II in the fine-tuning of metabolism and body composition. The underlying mechanisms and the potential clinical implications are discussed.
- Body composition
- Insulin receptor
- Insulin-like growth factor I
- Insulin-like growth factor II
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism