Abstract
Insulin-like growth factor-II (IGF-II), traditionally considered as a growth factor implicated in growth of fetal tissues and cancer cells, is now emerging as a potential metabolic regulator. The aim of this overview is to provide the available evidence, obtained in both experimen- tal conditions and in humans, for a role of IGF-II in the fine-tuning of metabolism and body composition. The underlying mechanisms and the potential clinical implications are discussed.
Original language | English |
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Article number | Article 118 |
Journal | Frontiers in Endocrinology |
Volume | 3 |
Issue number | OCT |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Body composition
- Insulin
- Insulin receptor
- Insulin-like growth factor I
- Insulin-like growth factor II
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism