TY - JOUR
T1 - Insulin-like growth factors (IGF-I and -II)
T2 - New actors in the development of non-alcoholic fatty liver disease
AU - Inzaghi, Elena
AU - Cianfarani, Stefano
AU - Nobili, Valerio
PY - 2014
Y1 - 2014
N2 - Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide, affecting 20-30% of adults and 3-10% of children in Western countries. The pathogenesis of NAFLD is considered to be multifactorial and factors such as insulin resistance, intrahepatic fat accumulation, oxidative stress, mitochondrial alterations, and stellate cell activation appear to substantially contribute to the development and progression of the disease. In this Editorial, we highlight some evidence suggesting a close link between NAFLD and growth hormone (GH)-IGF (insulin-like growth factor) axis.
AB - Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide, affecting 20-30% of adults and 3-10% of children in Western countries. The pathogenesis of NAFLD is considered to be multifactorial and factors such as insulin resistance, intrahepatic fat accumulation, oxidative stress, mitochondrial alterations, and stellate cell activation appear to substantially contribute to the development and progression of the disease. In this Editorial, we highlight some evidence suggesting a close link between NAFLD and growth hormone (GH)-IGF (insulin-like growth factor) axis.
KW - Children
KW - Cytokines
KW - Fatty liver
KW - Gh therapy
KW - IGFs
UR - http://www.scopus.com/inward/record.url?scp=84899111258&partnerID=8YFLogxK
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U2 - 10.1586/17446651.2014.900438
DO - 10.1586/17446651.2014.900438
M3 - Article
AN - SCOPUS:84899111258
VL - 9
SP - 193
EP - 195
JO - Expert Review of Endocrinology and Metabolism
JF - Expert Review of Endocrinology and Metabolism
SN - 1744-6651
IS - 3
ER -