Abstract
Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P
Original language | English |
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Pages (from-to) | 290-293 |
Number of pages | 4 |
Journal | Hypertension |
Volume | 26 |
Issue number | 2 |
Publication status | Published - 1995 |
Keywords
- aortic rings
- hyperinsulinemia
- hypertension, genetic
- insulin resistance
- norepinephrine
ASJC Scopus subject areas
- Internal Medicine