Abstract
Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P
| Original language | English |
|---|---|
| Pages (from-to) | 290-293 |
| Number of pages | 4 |
| Journal | Hypertension |
| Volume | 26 |
| Issue number | 2 |
| Publication status | Published - 1995 |
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Keywords
- aortic rings
- hyperinsulinemia
- hypertension, genetic
- insulin resistance
- norepinephrine
ASJC Scopus subject areas
- Internal Medicine
Cite this
Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats. / Lembo, G.; Iaccarino, G.; Vecchione, C.; Rendina, V.; Trimarco, B.
In: Hypertension, Vol. 26, No. 2, 1995, p. 290-293.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats
AU - Lembo, G.
AU - Iaccarino, G.
AU - Vecchione, C.
AU - Rendina, V.
AU - Trimarco, B.
PY - 1995
Y1 - 1995
N2 - Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P
AB - Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P
KW - aortic rings
KW - hyperinsulinemia
KW - hypertension, genetic
KW - insulin resistance
KW - norepinephrine
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M3 - Article
VL - 26
SP - 290
EP - 293
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2
ER -