Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats

G. Lembo; G. Iaccarino; C. Vecchione; V. Rendina; B. Trimarco

Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats

G. Lembo, G. Iaccarino, C. Vecchione, V. Rendina, B. Trimarco

Research output: Contribution to journal › Article › peer-review

Abstract

Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 10⁵ mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P

Original language	English
Pages (from-to)	290-293
Number of pages	4
Journal	Hypertension
Volume	26
Issue number	2
Publication status	Published - 1995

Keywords

aortic rings
hyperinsulinemia
hypertension, genetic
insulin resistance
norepinephrine

ASJC Scopus subject areas

Internal Medicine

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title = "Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats",

abstract = "Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P",

keywords = "aortic rings, hyperinsulinemia, hypertension, genetic, insulin resistance, norepinephrine",

author = "G. Lembo and G. Iaccarino and C. Vecchione and V. Rendina and B. Trimarco",

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T1 - Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats

AU - Lembo, G.

AU - Iaccarino, G.

AU - Vecchione, C.

AU - Rendina, V.

AU - Trimarco, B.

PY - 1995

Y1 - 1995

N2 - Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P

AB - Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P

KW - aortic rings

KW - hyperinsulinemia

KW - hypertension, genetic

KW - insulin resistance

KW - norepinephrine

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JO - Hypertension

JF - Hypertension

SN - 0194-911X

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ER -

Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats

Abstract

Keywords

ASJC Scopus subject areas

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