Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats

G. Lembo, G. Iaccarino, C. Vecchione, V. Rendina, B. Trimarco

Research output: Contribution to journalArticle


Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P

Original languageEnglish
Pages (from-to)290-293
Number of pages4
Issue number2
Publication statusPublished - 1995



  • aortic rings
  • hyperinsulinemia
  • hypertension, genetic
  • insulin resistance
  • norepinephrine

ASJC Scopus subject areas

  • Internal Medicine

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