Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats

G. Lembo; G. Iaccarino; C. Vecchione; V. Rendina; B. Trimarco

Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats

G. Lembo, G. Iaccarino, C. Vecchione, V. Rendina, B. Trimarco

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Abstract

Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 10⁵ mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P

Original language	English
Pages (from-to)	290-293
Number of pages	4
Journal	Hypertension
Volume	26
Issue number	2
Publication status	Published - 1995

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Keywords

aortic rings
hyperinsulinemia
hypertension, genetic
insulin resistance
norepinephrine

ASJC Scopus subject areas

Internal Medicine

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Lembo, G., Iaccarino, G., Vecchione, C., Rendina, V., & Trimarco, B. (1995). Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats. Hypertension, 26(2), 290-293.

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abstract = "Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P",

keywords = "aortic rings, hyperinsulinemia, hypertension, genetic, insulin resistance, norepinephrine",

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AU - Lembo, G.

AU - Iaccarino, G.

AU - Vecchione, C.

AU - Rendina, V.

AU - Trimarco, B.

PY - 1995

Y1 - 1995

N2 - Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P

AB - Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n = 10) and after (15 weeks old, n = 10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n = 14; 15 weeks old, n = 13). Blood pressure was significantly higher in SHR compared with WKY (181 ± 5 versus 118 ± 6 mm Hg, respectively, P16 to 105 mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F = 2.443, P

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KW - hyperinsulinemia

KW - hypertension, genetic

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JO - Hypertension

JF - Hypertension

SN - 0194-911X

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Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats

Abstract

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Keywords

ASJC Scopus subject areas

Cite this

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