In nine patients with myotonic dystrophy and in nine control subjects we evaluated insulin receptor activity on mononuclear leucocytes. The results demonstrated that in myotonic dystrophy: 1° insulin binding to specific receptors is significantly impaired for a numerical reduction of high affinity and low affinity receptors; 2° the affinity constants were not significantly affected; 3° no correlation exists between receptor activity, insulin behavior and glucose tolerance. These data suggest that the constant numerical reduction of insulin receptors is probably due to a systemic membrane defect, typical of myotonic dystrophy.
|Number of pages||10|
|Journal||Acta Neurologica Belgica|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Clinical Neurology