Insulin receptors in myotonic dystrophy

P. Fratino, G. Bellomo, R. Bellazzi, E. Martignoni, G. Nappi

Research output: Contribution to journalArticle

Abstract

In nine patients with myotonic dystrophy and in nine control subjects we evaluated insulin receptor activity on mononuclear leucocytes. The results demonstrated that in myotonic dystrophy: 1° insulin binding to specific receptors is significantly impaired for a numerical reduction of high affinity and low affinity receptors; 2° the affinity constants were not significantly affected; 3° no correlation exists between receptor activity, insulin behavior and glucose tolerance. These data suggest that the constant numerical reduction of insulin receptors is probably due to a systemic membrane defect, typical of myotonic dystrophy.

Original languageEnglish
Pages (from-to)128-137
Number of pages10
JournalActa Neurologica Belgica
Volume82
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Clinical Neurology

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    Fratino, P., Bellomo, G., Bellazzi, R., Martignoni, E., & Nappi, G. (1982). Insulin receptors in myotonic dystrophy. Acta Neurologica Belgica, 82(3), 128-137.