Insulin receptors in myotonic dystrophy: A study with mononuclear leucocytes and erythrocytes

P. Fratino, G. Bellomo, R. Bellazzi, P. L. Nicotera, G. Sandrini, G. Nappi

Research output: Contribution to journalArticle

Abstract

We evaluated insulin receptor activity on mononuclear leucocytes and erythrocytes in 9 patients with myotonic dystrophy and in 9 controls. The results demonstrated that in myotonic dystrophy: 1. insulin binding to specific receptors was significantly impaired (P <0.01) because of a reduction in the number of high and low affinity receptors. 2. the affinity constants were not significantly affected 3. there was no correlation between receptor activity, insulin behaviour and glucose tolerance. These data obtained in two different cellular systems suggest that the constant numerical reduction of insulin receptors was probably due to a systemic membrane defect, typical of myotonic dystrophy.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalItalian Journal of Neurological Sciences
Volume3
Issue number2
DOIs
Publication statusPublished - Jun 1982

Keywords

  • erythrocytes
  • Insulin receptors, myotonic dystrophy
  • mononuclear leucocytes
  • serum insulin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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