Abstract
The aim of the present study was to analyze whether aging also affects central insulin receptors in brain cortex as it does in whole brain of BALB/c-nu mice. Results showed statistically significant decrease of number and increase of affinity of insulin high affinity binding sites in old animals. As a consequence, central insulin actions, among which neuromodulation of monoaminergic system, can result altered during aging. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Original language | English |
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Pages (from-to) | 227-232 |
Number of pages | 6 |
Journal | Mechanisms of Ageing and Development |
Volume | 113 |
Issue number | 3 |
DOIs | |
Publication status | Published - Feb 15 2000 |
Keywords
- Aging
- Brain cortex
- Insulin receptors
- Mouse
ASJC Scopus subject areas
- Ageing
- Biochemistry
- Developmental Biology
- Developmental Neuroscience