Insulin receptors in the brain cortex of aging mice

Annamaria Zaia; Lucio Piantanelli

doi:10.1016/S0047-6374(99)00118-9

Insulin receptors in the brain cortex of aging mice

Annamaria Zaia, Lucio Piantanelli

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of the present study was to analyze whether aging also affects central insulin receptors in brain cortex as it does in whole brain of BALB/c-nu mice. Results showed statistically significant decrease of number and increase of affinity of insulin high affinity binding sites in old animals. As a consequence, central insulin actions, among which neuromodulation of monoaminergic system, can result altered during aging. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	227-232
Number of pages	6
Journal	Mechanisms of Ageing and Development
Volume	113
Issue number	3
DOIs	https://doi.org/10.1016/S0047-6374(99)00118-9
Publication status	Published - Feb 15 2000

Keywords

Aging
Brain cortex
Insulin receptors
Mouse

ASJC Scopus subject areas

Ageing
Biochemistry
Developmental Biology
Developmental Neuroscience

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