Insulin receptors in the brain cortex of aging mice

Annamaria Zaia, Lucio Piantanelli

Research output: Contribution to journalArticlepeer-review


The aim of the present study was to analyze whether aging also affects central insulin receptors in brain cortex as it does in whole brain of BALB/c-nu mice. Results showed statistically significant decrease of number and increase of affinity of insulin high affinity binding sites in old animals. As a consequence, central insulin actions, among which neuromodulation of monoaminergic system, can result altered during aging. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalMechanisms of Ageing and Development
Issue number3
Publication statusPublished - Feb 15 2000


  • Aging
  • Brain cortex
  • Insulin receptors
  • Mouse

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience


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