Insulin reduces HBsAg production by PLC/PRF/5 human hepatoma cell line

M. Clementi, I. Testa, P. Bagnarelli, A. Festa, P. Pauri, M. Brugia, L. Calegari, C. de Martinis

Research output: Contribution to journalArticlepeer-review


Although its action at the molecular level is not completely understood, insulin, as well as its antagonist glucagon, certaily plays an important role in the modulation of protein synthesis. In order to observe whether insulin is involved in virus gene expression, we studied its effect on PLC/PRF/5 human hepatoma cell line, which posses HBV DNA sequences integrated at several sites. While human insulin had no effect on cell growth and increased the production of two plasma proteins, a selective inhibitory effect on HBsAg production could be detected. This observation might be useful for further studies both on virus gene expression and insulin action at the molecular level.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalArchives of Virology
Issue number1-2
Publication statusPublished - Mar 1984

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics


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