Insulin reduces reflex forearm sympathetic vasoconstriction in healthy humans

Giuseppe Lembo, Virgilio Rendina, Guido Iaccarino, Fausto Lamenza, Massimo Volpe, Bruno Trimarco

Research output: Contribution to journalArticle

Abstract

Previous In vitro studies indicate that insulin modifies vascular reactivity to different agents. We have previously demonstrated that in normotensive humans physiological hyperinsutinemia is associated with an increase of forearm norepinephrine release but does not modify vascular resistance. To explore whether insulin modulates peripheral vasoconstriction induced by reflex sympathetic activation, we studied its effects on forearm hemodynamics (strain-gauge plethysmography) during graded levels of lower body negative pressure (—5, —10, —15, and —20 mtn Hg, each for 5 minutes) in normotensive subjects. For this purpose, eight subjects received an intrabrachial artery infusion of regular insulin at a systemicaIly ineffective rate (0.05 milliunits/kg per minute) so that deep-venous insulin levels increased in the experimental forearm from 16.5±2.9 to 379.6±30 pmol/L (p

Original languageEnglish
Pages (from-to)1015-1019
Number of pages5
JournalHypertension
Volume21
Issue number6
Publication statusPublished - 1993

Keywords

  • Insulin
  • Lower body negative pressure
  • Norepinephrine
  • Sympathetic nervous system
  • Vascular resistance

ASJC Scopus subject areas

  • Internal Medicine

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    Lembo, G., Rendina, V., Iaccarino, G., Lamenza, F., Volpe, M., & Trimarco, B. (1993). Insulin reduces reflex forearm sympathetic vasoconstriction in healthy humans. Hypertension, 21(6), 1015-1019.