Abstract
The purpose of this study is to investigate the relationship between acne and insulin resistance as well as other metabolic impairment in young males. Acne is a skin disease that can be influenced by endocrine abnormalities. In females, it is associated with polycystic ovary syndrome, with peripheral insulin resistance and hyperinsulinemia, whereas few data are available in males. For investigating this, 22 young males with acne have been compared to 22 controls of comparable age and gender. Acne was scored using the global acne grading system score. Clinical as well as biochemical parameters of glucose and lipid metabolism, circulating levels of androgens, and IGF-1 were evaluated. Oral glucose tolerance test was performed and homeostasis model assessment of insulin resistance was calculated. The results thus obtained are as follows, patients had higher BMI (p = 0.003), WC (p = 0.002), WHR (p = 0.02), SBP (p = 0.0001), DBP (p = 0.001), basal (p = 0.01) and 120 min. oGTT serum insulin concentrations (p = 0.002), basal glucose concentrations (p = 0.03), HOMA-IR (p = 0.016), and lower HDL-cholesterol than controls (p = 0.001). Among the subgroup of subjects with BMI
| Original language | English |
|---|---|
| Pages (from-to) | 555-560 |
| Number of pages | 6 |
| Journal | Endocrine |
| Volume | 42 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 2012 |
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Keywords
- Acne
- HDL-cholesterol
- Insulin
- Insulin resistance
- Male acne
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Insulin resistance and acne : A new risk factor for men? / Del Prete, Michela; Mauriello, Maria Chiara; Faggiano, Antongiulio; Di Somma, Carolina; Monfrecola, Giuseppe; Fabbrocini, Gabriella; Colao, Annamaria.
In: Endocrine, Vol. 42, No. 3, 12.2012, p. 555-560.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin resistance and acne
T2 - A new risk factor for men?
AU - Del Prete, Michela
AU - Mauriello, Maria Chiara
AU - Faggiano, Antongiulio
AU - Di Somma, Carolina
AU - Monfrecola, Giuseppe
AU - Fabbrocini, Gabriella
AU - Colao, Annamaria
PY - 2012/12
Y1 - 2012/12
N2 - The purpose of this study is to investigate the relationship between acne and insulin resistance as well as other metabolic impairment in young males. Acne is a skin disease that can be influenced by endocrine abnormalities. In females, it is associated with polycystic ovary syndrome, with peripheral insulin resistance and hyperinsulinemia, whereas few data are available in males. For investigating this, 22 young males with acne have been compared to 22 controls of comparable age and gender. Acne was scored using the global acne grading system score. Clinical as well as biochemical parameters of glucose and lipid metabolism, circulating levels of androgens, and IGF-1 were evaluated. Oral glucose tolerance test was performed and homeostasis model assessment of insulin resistance was calculated. The results thus obtained are as follows, patients had higher BMI (p = 0.003), WC (p = 0.002), WHR (p = 0.02), SBP (p = 0.0001), DBP (p = 0.001), basal (p = 0.01) and 120 min. oGTT serum insulin concentrations (p = 0.002), basal glucose concentrations (p = 0.03), HOMA-IR (p = 0.016), and lower HDL-cholesterol than controls (p = 0.001). Among the subgroup of subjects with BMI
AB - The purpose of this study is to investigate the relationship between acne and insulin resistance as well as other metabolic impairment in young males. Acne is a skin disease that can be influenced by endocrine abnormalities. In females, it is associated with polycystic ovary syndrome, with peripheral insulin resistance and hyperinsulinemia, whereas few data are available in males. For investigating this, 22 young males with acne have been compared to 22 controls of comparable age and gender. Acne was scored using the global acne grading system score. Clinical as well as biochemical parameters of glucose and lipid metabolism, circulating levels of androgens, and IGF-1 were evaluated. Oral glucose tolerance test was performed and homeostasis model assessment of insulin resistance was calculated. The results thus obtained are as follows, patients had higher BMI (p = 0.003), WC (p = 0.002), WHR (p = 0.02), SBP (p = 0.0001), DBP (p = 0.001), basal (p = 0.01) and 120 min. oGTT serum insulin concentrations (p = 0.002), basal glucose concentrations (p = 0.03), HOMA-IR (p = 0.016), and lower HDL-cholesterol than controls (p = 0.001). Among the subgroup of subjects with BMI
KW - Acne
KW - HDL-cholesterol
KW - Insulin
KW - Insulin resistance
KW - Male acne
UR - http://www.scopus.com/inward/record.url?scp=84876875700&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876875700&partnerID=8YFLogxK
U2 - 10.1007/s12020-012-9647-6
DO - 10.1007/s12020-012-9647-6
M3 - Article
C2 - 22447309
AN - SCOPUS:84876875700
VL - 42
SP - 555
EP - 560
JO - Endocrine
JF - Endocrine
SN - 1355-008X
IS - 3
ER -