Insulin resistance and bone: a biological partnership

C Conte, S Epstein, N Napoli

Research output: Contribution to journalArticlepeer-review


Despite a clear association between type 2 diabetes (T2D) and fracture risk, the pathogenesis of bone fragility in T2D has not been clearly elucidated. Insulin resistance is the primary defect in T2D. Insulin signalling regulates both bone formation and bone resorption, but whether insulin resistance can affect bone has not been established. On the other hand, evidence exists that bone might play a role in the regulation of glucose metabolism. This article reviews the available experimental and clinical evidence on the interplay between bone and insulin resistance. Interestingly, a bilateral relationship between bone and insulin resistance seems to exist that unites them in a biological partnership. © 2018, Springer-Verlag Italia S.r.l., part of Springer Nature.
Original languageEnglish
Pages (from-to)305-314
Number of pages10
JournalActa Diabetologica
Issue number4
Publication statusPublished - 2018


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