Insulin resistance in patients with cardiac hypertrophy

Giovanni Paternostro, Domenico Pagano, Tomaso Gnecchi-Ruscone, Robert S. Bonser, Paolo G. Camici

Research output: Contribution to journalArticle

Abstract

Objective: Animal studies suggest that left ventricular hypertrophy might be associated with insulin resistance and alterations in glucose transporters. We have previously demonstrated myocardial insulin resistance in patients with post-ischemic heart failure. The aim was to investigate whether myocardial insulin resistance could be demonstrated in human cardiac hypertrophy in the absence of hypertension, diabetes and coronary artery disease. Methods: Eleven normotensive nondiabetic patients with cardiac hypertrophy due to aortic stenosis and angiographically normal coronary arteries were compared to 11 normal volunteers. Myocardial glucose uptake (MGU) was measured with positron emission tomography and [18F]2-fluoro-2- deoxy-D-glucose during fasting (low insulinemia) or during euglycemic- hyperinsulinemic clamp (physiologic hyperinsulinemia). Myocardial biopsies were obtained in order to investigate changes in insulin-independent (GLUT- 1) and insulin-dependent (GLUT-4) glucose transporters. Results: During fasting, plasma insulin (7±1 vs. 6±1 mU/l) and MGU (0.12±0.05 vs. 0.11±0.04 μmol/min/g) were comparable in patients and controls. By contrast, during clamp, MGU was markedly reduced in patients (0.48±0.02 vs. 0.70+0.03 μmol/min/g, p

Original languageEnglish
Pages (from-to)246-253
Number of pages8
JournalCardiovascular Research
Volume42
Issue number1
DOIs
Publication statusPublished - Apr 1 1999

Keywords

  • Glycolysis
  • Heart failure
  • Hyertrophy
  • Membrane transport
  • Positron emission tomography
  • Valve (disease)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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