Insulin secretion, nutritional status and respiratory function in cystic fibrosis patients with normal glucose tolerance

Gianfranco Alicandro, Pier Maria Battezzati, Alberto Battezzati, Chiara Speziali, Laura Claut, Valentina Motta, Silvana Loi, Carla Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

Background & aims: Impaired growth and nutritional status in CF may be related to progressive insulin deficiency before CF-Related Diabetes has established. Aim of this study was to analyse the association of circulating insulin with nutritional status and lung function in CF patients with normal glucose tolerance (NGT). Methods: We performed OGTT in 152 consecutive CF patients aged 8-20 years: 115 of them had NGT and were included in the study. Areas under the curves (AUC) of glucose, insulin and c-peptide after 120min were calculated. Quartiles (Q) of increasing fasting insulin (fINS-Q) and c-peptide (fCP-Q) levels were calculated in CF patients. Respiratory function parameters (FEV1, FVC), Standard Deviation Scores (SDS) of height, weight and BMI were compared between Q1 and the three higher Q. Multiple regression analysis was used to analyse the association of fasting insulin, c-peptide or OGTT derived indices with nutritional or respiratory parameters. Results: Compared to patients in fINS-Q4 or fCP-Q4, those in fINS-Q1 or in fCP-Q1 respectively showed lower levels of insulin AUC or c-peptide AUC (both P

Original languageEnglish
Pages (from-to)118-123
Number of pages6
JournalClinical Nutrition
Volume31
Issue number1
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Cystic fibrosis
  • Growth
  • Insulin
  • Nutritional status
  • Respiratory function

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

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