Insulin secretion rate and β-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans

Francesco Di Nardo, Pamela Cerasa, Fabrizio Casagrande, Massimo Boemi, Pierpaolo Morosini, Roberto Burattini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Aim of the study was to test the reproducibility of estimates of static, Φs, and dynamic, Φd, β-cell sensitivity to glucose, and predictions of the insulin secretion rate, SR(t), provided by the C-peptide oral minimal model (COMM) applied to oral glucose tolerance tests (OGTT) of various complexity. The study involved six volunteer, normotensive and normoglycemic subjects who underwent a 300-minute OGTT. Results from a full 22-sampling schedule (OGTT300/22), were compared with those from two reduced schedules consisting of 11 samples in 300 min (OGTT300/11) and 7 samples in 120 min (OGTT120/7). Our results showed that both reduced-sample protocols did not affect significantly the estimates of Φd. Intraclass correlation coefficients were higher than 0.9. The Φs appeared more sensitive to reductions of protocol complexity. Nevertheless, intraclass correlation coefficients kept higher than 0.7. No significant differences were found in model predictions of SR(t) profiles among all tested OGTT protocols. These findings confirm the COMM as a potentially useful tool to quantify β-cell sensitivity and insulin secretion rate in pathophysiological studies, from relatively low-cost OGTT.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages449-450
Number of pages2
DOIs
Publication statusPublished - 2006
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

ASJC Scopus subject areas

  • Bioengineering

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