Insulin secretion rate and β-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans

Francesco Di Nardo; Pamela Cerasa; Fabrizio Casagrande; Massimo Boemi; Pierpaolo Morosini; Roberto Burattini

doi:10.1109/IEMBS.2006.260216

Insulin secretion rate and β-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans

Francesco Di Nardo, Pamela Cerasa, Fabrizio Casagrande, Massimo Boemi, Pierpaolo Morosini, Roberto Burattini

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Aim of the study was to test the reproducibility of estimates of static, Φ_s, and dynamic, Φ_d, β-cell sensitivity to glucose, and predictions of the insulin secretion rate, SR(t), provided by the C-peptide oral minimal model (COMM) applied to oral glucose tolerance tests (OGTT) of various complexity. The study involved six volunteer, normotensive and normoglycemic subjects who underwent a 300-minute OGTT. Results from a full 22-sampling schedule (OGTT_300/22), were compared with those from two reduced schedules consisting of 11 samples in 300 min (OGTT_300/11) and 7 samples in 120 min (OGTT_120/7). Our results showed that both reduced-sample protocols did not affect significantly the estimates of Φ_d. Intraclass correlation coefficients were higher than 0.9. The Φ_s appeared more sensitive to reductions of protocol complexity. Nevertheless, intraclass correlation coefficients kept higher than 0.7. No significant differences were found in model predictions of SR(t) profiles among all tested OGTT protocols. These findings confirm the COMM as a potentially useful tool to quantify β-cell sensitivity and insulin secretion rate in pathophysiological studies, from relatively low-cost OGTT.

Original language	English
Title of host publication	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages	449-450
Number of pages	2
DOIs	https://doi.org/10.1109/IEMBS.2006.260216
Publication status	Published - 2006
Event	28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States Duration: Aug 30 2006 → Sep 3 2006

Other

Other	28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Country	United States
City	New York, NY
Period	8/30/06 → 9/3/06

ASJC Scopus subject areas

Bioengineering

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Di Nardo, F., Cerasa, P., Casagrande, F., Boemi, M., Morosini, P., & Burattini, R. (2006). Insulin secretion rate and β-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 449-450). [4029015] https://doi.org/10.1109/IEMBS.2006.260216

Insulin secretion rate and β-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans. / Di Nardo, Francesco; Cerasa, Pamela; Casagrande, Fabrizio; Boemi, Massimo; Morosini, Pierpaolo; Burattini, Roberto.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 449-450 4029015.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Di Nardo, F, Cerasa, P, Casagrande, F, Boemi, M, Morosini, P & Burattini, R 2006, Insulin secretion rate and β-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4029015, pp. 449-450, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, United States, 8/30/06. https://doi.org/10.1109/IEMBS.2006.260216

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