Insulin secretion rate and beta-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans.

Francesco Di Nardo, Pamela Cerasa, Fabrizio Casagrande, Massimo Boemi, Pierpaolo Morosini, Roberto Burattini

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Abstract

Aim of the study was to test the reproducibility of estimates of static, Phi s, and dynamic, Phi d, beta-cell sensitivity to glucose, and predictions of the insulin secretion rate, SR(t), provided by the C-peptide oral minimal model (COMM) applied to oral glucose tolerance tests (OGTT) of various complexity. The study involved six volunteer, normotensive and normoglycemic subjects who underwent a 300-minute OGTT. Results from a full 22-sampling schedule (OGTT300/22), were compared with those from two reduced schedules consisting of 11 samples in 300 min (OGTT300/11) and 7 samples in 120 min (OGTT120/7). Our results showed that both reduced-sample protocols did not affect significantly the estimates of Phi d. Intraclass correlation coefficients were higher than 0.9. The Phi s appeared more sensitive to reductions of protocol complexity. Nevertheless, intraclass correlation coefficients kept higher than 0.7. No significant differences were found in model predictions of SR(t) profiles among all tested OGTT protocols. These findings confirm the COMM as a potentially useful tool to quantify beta-cell sensitivity and insulin secretion rate in pathophysiological studies, from relatively low-cost OGTT.

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Insulin
Glucose Tolerance Test
Glucose
C-Peptide
Appointments and Schedules
Peptides
Insulin Resistance
Volunteers
Costs and Cost Analysis
Sampling
Costs

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

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title = "Insulin secretion rate and beta-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans.",
abstract = "Aim of the study was to test the reproducibility of estimates of static, Phi s, and dynamic, Phi d, beta-cell sensitivity to glucose, and predictions of the insulin secretion rate, SR(t), provided by the C-peptide oral minimal model (COMM) applied to oral glucose tolerance tests (OGTT) of various complexity. The study involved six volunteer, normotensive and normoglycemic subjects who underwent a 300-minute OGTT. Results from a full 22-sampling schedule (OGTT300/22), were compared with those from two reduced schedules consisting of 11 samples in 300 min (OGTT300/11) and 7 samples in 120 min (OGTT120/7). Our results showed that both reduced-sample protocols did not affect significantly the estimates of Phi d. Intraclass correlation coefficients were higher than 0.9. The Phi s appeared more sensitive to reductions of protocol complexity. Nevertheless, intraclass correlation coefficients kept higher than 0.7. No significant differences were found in model predictions of SR(t) profiles among all tested OGTT protocols. These findings confirm the COMM as a potentially useful tool to quantify beta-cell sensitivity and insulin secretion rate in pathophysiological studies, from relatively low-cost OGTT.",
author = "{Di Nardo}, Francesco and Pamela Cerasa and Fabrizio Casagrande and Massimo Boemi and Pierpaolo Morosini and Roberto Burattini",
year = "2006",
language = "English",
pages = "449--450",
journal = "Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference",
issn = "1557-170X",
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TY - JOUR

T1 - Insulin secretion rate and beta-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans.

AU - Di Nardo, Francesco

AU - Cerasa, Pamela

AU - Casagrande, Fabrizio

AU - Boemi, Massimo

AU - Morosini, Pierpaolo

AU - Burattini, Roberto

PY - 2006

Y1 - 2006

N2 - Aim of the study was to test the reproducibility of estimates of static, Phi s, and dynamic, Phi d, beta-cell sensitivity to glucose, and predictions of the insulin secretion rate, SR(t), provided by the C-peptide oral minimal model (COMM) applied to oral glucose tolerance tests (OGTT) of various complexity. The study involved six volunteer, normotensive and normoglycemic subjects who underwent a 300-minute OGTT. Results from a full 22-sampling schedule (OGTT300/22), were compared with those from two reduced schedules consisting of 11 samples in 300 min (OGTT300/11) and 7 samples in 120 min (OGTT120/7). Our results showed that both reduced-sample protocols did not affect significantly the estimates of Phi d. Intraclass correlation coefficients were higher than 0.9. The Phi s appeared more sensitive to reductions of protocol complexity. Nevertheless, intraclass correlation coefficients kept higher than 0.7. No significant differences were found in model predictions of SR(t) profiles among all tested OGTT protocols. These findings confirm the COMM as a potentially useful tool to quantify beta-cell sensitivity and insulin secretion rate in pathophysiological studies, from relatively low-cost OGTT.

AB - Aim of the study was to test the reproducibility of estimates of static, Phi s, and dynamic, Phi d, beta-cell sensitivity to glucose, and predictions of the insulin secretion rate, SR(t), provided by the C-peptide oral minimal model (COMM) applied to oral glucose tolerance tests (OGTT) of various complexity. The study involved six volunteer, normotensive and normoglycemic subjects who underwent a 300-minute OGTT. Results from a full 22-sampling schedule (OGTT300/22), were compared with those from two reduced schedules consisting of 11 samples in 300 min (OGTT300/11) and 7 samples in 120 min (OGTT120/7). Our results showed that both reduced-sample protocols did not affect significantly the estimates of Phi d. Intraclass correlation coefficients were higher than 0.9. The Phi s appeared more sensitive to reductions of protocol complexity. Nevertheless, intraclass correlation coefficients kept higher than 0.7. No significant differences were found in model predictions of SR(t) profiles among all tested OGTT protocols. These findings confirm the COMM as a potentially useful tool to quantify beta-cell sensitivity and insulin secretion rate in pathophysiological studies, from relatively low-cost OGTT.

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