Insulin sensitivity deteriorates after short-term lifestyle intervention in the insulin sensitive phenotype of obesity

Luisa Gilardini, Luciana Vallone, Raffaella Cottafava, Gabriella Redaelli, Marina Croci, Antonio Conti, Lucia Pasqualinotto, Cecilia Invitti

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To investigate the effects of a 3-month lifestyle intervention on insulin sensitivity and its related cardiometabolic factors in obese patients. Methods: Anthropometry, body composition, oral glucose tolerance test, lipids, alanine aminotransferase, insulin sensitivity (insulinogenic index (ISI), homeostasis model assessment, β-cell performance (disposition index)) were evaluated in 263 obese women and 93 obese men before and after 3 months of hypocaloric low fat/high protein diet associated with physical activity 30 min/day. Results: Patients were divided into 3 groups according to the intervention-induced ISI changes: group 1 (decrease), group 2 (stability) and group 3 (increase). Insulin sensitivity and the disposition index were significantly higher before the intervention in group 1 than in group 3. BMI, waist circumference, and fat mass significantly decreased in groups 1 and 3 in both sexes. β-cell performance decreased in group 1 and increased in group 3. Metabolic variables improved in group 3, whereas glucose levels increased in women of group 1. The post-intervention insulin sensitivity was lower in group 1 than in group 3. Conclusion: Lifestyle intervention induces changes in insulin sensitivity and metabolic factors that depend on the pre-intervention degree of insulin sensitivity. Weight loss leads to metabolic benefits in insulin-resistant, obese patients, whereas it may paradoxically worsen the metabolic conditions in the insulin-sensitive phenotype of obesity.

Original languageEnglish
Pages (from-to)68-76
Number of pages9
JournalObesity Facts
Volume5
Issue number1
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Insulin Resistance
Life Style
Obesity
Insulin
Phenotype
Group
Anthropometry
Waist Circumference
High Fat Diet
Glucose Tolerance Test
Body Composition
Alanine Transaminase
disposition
Weight Loss
Homeostasis
Fats
Exercise
Lipids
Glucose
performance

Keywords

  • β-Cell performance
  • Insulin sensitivity
  • Lifestyle intervention
  • Obesity
  • Weight loss

ASJC Scopus subject areas

  • Physiology (medical)
  • Health(social science)

Cite this

Insulin sensitivity deteriorates after short-term lifestyle intervention in the insulin sensitive phenotype of obesity. / Gilardini, Luisa; Vallone, Luciana; Cottafava, Raffaella; Redaelli, Gabriella; Croci, Marina; Conti, Antonio; Pasqualinotto, Lucia; Invitti, Cecilia.

In: Obesity Facts, Vol. 5, No. 1, 03.2012, p. 68-76.

Research output: Contribution to journalArticle

Gilardini, Luisa ; Vallone, Luciana ; Cottafava, Raffaella ; Redaelli, Gabriella ; Croci, Marina ; Conti, Antonio ; Pasqualinotto, Lucia ; Invitti, Cecilia. / Insulin sensitivity deteriorates after short-term lifestyle intervention in the insulin sensitive phenotype of obesity. In: Obesity Facts. 2012 ; Vol. 5, No. 1. pp. 68-76.
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