Insulin Sensitivity from Preschool to School Age in Patients with Severe Obesity

Melania Manco, Maria Rita Spreghini, Rosa Luciano, Cecilia Pensini, Rita Wietrzycowska Sforza, Carmela Rustico, Marco Cappa, Giuseppe Stefano Morino

Research output: Contribution to journalArticlepeer-review


Background:Insulin sensitivity decreases at puberty transition, but little information has been provided on its earlier time-course. Aim of the present study was to describe the time-course of insulin sensitivity in severely obese children at the transition from preschool to school age.Research design and methods:Retrospective study of a cohort of 47 severely obese [Body Mass Index (BMI) ≥99° percentile] preschoolers evaluated twice, once between 2 and 6 years of age, and once before age 8. Glucose tolerance, Whole Body Insulin Sensitivity Index (WBISI), Insulinogenic Index (IGI); β-cell demand index (BCDI) and Insulin Secretion-Sensitivity Index 2 (ISSI-2) were longitudinally estimated during the oral glucose tolerance test.Results:After a median follow-up of 2.23 (1-4.52) y, obese patients showed significant decrease in WBISI (p2 = 0.309; p = 0.002; β = -0.556), ISSI-2 (R2 = 0.465; p2 = 0.246; p = 0.008; 0.496), respectively.Conclusions:In morbidly obese children, insulin sensitivity seems to decline even before pubertal transition, but changes in total adiposity can only partially explain this variation.

Original languageEnglish
Article numbere68628
JournalPLoS One
Issue number7
Publication statusPublished - Jul 31 2013

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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