Abstract
The standard measures of insulin sensitivity, SI , obtained e.g. by clamp or minimal model (MM) techniques, do not account for how fast/slow insulin action reaches its plateau value. Recently, we have proposed a new dynamic insulin sensitivity index, S I D, that incorporates this information. We have shown that in normal subjects S I D offers, in comparison with S I, a more comprehensive picture of insulin action on glucose metabolism. Here, we illustrate how S I D is even more appropriate when studying type 2 diabetic patients whose insulin action is not only impaired in magnitude but also slow. In particular, by identifying MM from an intravenous glucose tolerance test (IVGTT) experiment in 10 diabetic subjects via a Bayesian strategy, we show that S I D is not only more informative but also more precise than SI .We conclude that S I D is the insulin sensitivity index of choice when studying subjects with impaired insulin action like impaired glucose tolerant or diabetics.
| Original language | English |
|---|---|
| Title of host publication | IFAC Proceedings Volumes (IFAC-PapersOnline) |
| Pages | 207-212 |
| Number of pages | 6 |
| Volume | 6 |
| Edition | PART 1 |
| Publication status | Published - 2006 |
| Event | 6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006 - Reims, France Duration: Aug 20 2006 → Aug 22 2006 |
Other
| Other | 6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006 |
|---|---|
| Country | France |
| City | Reims |
| Period | 8/20/06 → 8/22/06 |
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Keywords
- Bayesian estimation
- Biomedical systems
- Diabetes
- Insulin resistance
- Markov chain Monte Carlo
- Parameter estimation
ASJC Scopus subject areas
- Control and Systems Engineering
Cite this
Insulin sensitivity index also accounting for insulin action dynamics : Importance in diabetes. / Pillonetto, Gianluigi; Caumo, Andrea; Cobelli, Claudio.
IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 6 PART 1. ed. 2006. p. 207-212.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Insulin sensitivity index also accounting for insulin action dynamics
T2 - Importance in diabetes
AU - Pillonetto, Gianluigi
AU - Caumo, Andrea
AU - Cobelli, Claudio
PY - 2006
Y1 - 2006
N2 - The standard measures of insulin sensitivity, SI , obtained e.g. by clamp or minimal model (MM) techniques, do not account for how fast/slow insulin action reaches its plateau value. Recently, we have proposed a new dynamic insulin sensitivity index, S I D, that incorporates this information. We have shown that in normal subjects S I D offers, in comparison with S I, a more comprehensive picture of insulin action on glucose metabolism. Here, we illustrate how S I D is even more appropriate when studying type 2 diabetic patients whose insulin action is not only impaired in magnitude but also slow. In particular, by identifying MM from an intravenous glucose tolerance test (IVGTT) experiment in 10 diabetic subjects via a Bayesian strategy, we show that S I D is not only more informative but also more precise than SI .We conclude that S I D is the insulin sensitivity index of choice when studying subjects with impaired insulin action like impaired glucose tolerant or diabetics.
AB - The standard measures of insulin sensitivity, SI , obtained e.g. by clamp or minimal model (MM) techniques, do not account for how fast/slow insulin action reaches its plateau value. Recently, we have proposed a new dynamic insulin sensitivity index, S I D, that incorporates this information. We have shown that in normal subjects S I D offers, in comparison with S I, a more comprehensive picture of insulin action on glucose metabolism. Here, we illustrate how S I D is even more appropriate when studying type 2 diabetic patients whose insulin action is not only impaired in magnitude but also slow. In particular, by identifying MM from an intravenous glucose tolerance test (IVGTT) experiment in 10 diabetic subjects via a Bayesian strategy, we show that S I D is not only more informative but also more precise than SI .We conclude that S I D is the insulin sensitivity index of choice when studying subjects with impaired insulin action like impaired glucose tolerant or diabetics.
KW - Bayesian estimation
KW - Biomedical systems
KW - Diabetes
KW - Insulin resistance
KW - Markov chain Monte Carlo
KW - Parameter estimation
UR - http://www.scopus.com/inward/record.url?scp=79961138626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961138626&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:79961138626
SN - 9783902661180
VL - 6
SP - 207
EP - 212
BT - IFAC Proceedings Volumes (IFAC-PapersOnline)
ER -