Abstract
The muscarinic agonist oxotremorine produced a linear dose-dependent increase in membrane fluidity of intact and viable human lymphocytes in vitro. This effect proved to be receptor-mediated because preincubation with 10-5 M atropine shifted the dose-response curve one order of magnitude rightward. Pirenzepine preincubation did not affect membrane fluidity variation. A cGMP increase was also found after oxotremorine treatment. The results are discussed in terms of possible modulation ofguanyl cyclase and adenyl cyclase through membrane fluidity variations.
Original language | English |
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Pages (from-to) | 194-198 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 192 |
Issue number | 2 |
DOIs | |
Publication status | Published - Nov 18 1985 |
Keywords
- Atropine
- Cyclic GMP
- Lymphocyte
- Membrane fluidity
- Oxotremorine
- Pirenzepine
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology