Intake of Boron, Cadmium, and Molybdenum enhances rat thyroid cell transformation

E. Luca, L. Fici, A. Ronchi, F. Marandino, E. D. Rossi, M. E. Caristo, P. Malandrino, M. Russo, A. Pontecorvi, R. Vigneri, Fabiola Moretti

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Epidemiologic data in volcanic areas suggest that environmental factors might be involved in the increase of thyroid cancer (TC) incidence. Recent reports indicate that several heavy metals and metalloids are increased in volcanic areas. This study aims to evaluate the combined effect of three of these elements Boron (B), Cadmium (Cd), and Molybdenum (Mo) - all increased in the volcanic area of Mt. Etna, in Italy - on thyroid tumorigenesis in the rat. METHODS: Female Wistar rats prone to develop thyroid tumors by low-iodine diet and methimazole treatment received ad libitum drinking water supplemented with B, Cd, and Mo at concentrations in the range found in the urine samples of residents of the volcanic area. At 5 and 10 months animals were euthanized, and their thyroid analysed. Statistical analysis was performed with a 2-way unpaired t-test. RESULTS: No toxic effect of the three elements on the growth of the animals was observed. A significant increase of histological features of transformation was observed in thyroid follicular cells of rats treated with B, Cd, and Mo compared with those of control group. These abnormalities were associated with decreased iodine content in the thyroid. CONCLUSIONS: This study provides the evidence that slightly increased environmental concentrations of B, Cd, and Mo can accelerate the appearance of transformation marks in the thyroid gland of hypothyroid rats.
Original languageEnglish
Pages (from-to)73
JournalJournal of Experimental and Clinical Cancer Research
Volume36
Issue number1
DOIs
Publication statusPublished - Jun 2 2017

Fingerprint

Boron
Molybdenum
Cadmium
Thyroid Gland
Iodine
Metalloids
Methimazole
Poisons
Heavy Metals
Thyroid Neoplasms
Drinking Water
Italy
Wistar Rats
Carcinogenesis
Urine
Diet
Control Groups
Incidence
Growth
Neoplasms

Keywords

  • Boron
  • Cadmium
  • Heavy metals
  • Metalloids
  • Molybdenum
  • Thyroid
  • Thyroid cancer
  • Thyroid nodules
  • Volcanic area

Cite this

Intake of Boron, Cadmium, and Molybdenum enhances rat thyroid cell transformation. / Luca, E.; Fici, L.; Ronchi, A.; Marandino, F.; Rossi, E. D.; Caristo, M. E.; Malandrino, P.; Russo, M.; Pontecorvi, A.; Vigneri, R.; Moretti, Fabiola.

In: Journal of Experimental and Clinical Cancer Research, Vol. 36, No. 1, 02.06.2017, p. 73.

Research output: Contribution to journalArticle

Luca, E, Fici, L, Ronchi, A, Marandino, F, Rossi, ED, Caristo, ME, Malandrino, P, Russo, M, Pontecorvi, A, Vigneri, R & Moretti, F 2017, 'Intake of Boron, Cadmium, and Molybdenum enhances rat thyroid cell transformation', Journal of Experimental and Clinical Cancer Research, vol. 36, no. 1, pp. 73. https://doi.org/10.1186/s13046-017-0543-z [doi]
Luca, E. ; Fici, L. ; Ronchi, A. ; Marandino, F. ; Rossi, E. D. ; Caristo, M. E. ; Malandrino, P. ; Russo, M. ; Pontecorvi, A. ; Vigneri, R. ; Moretti, Fabiola. / Intake of Boron, Cadmium, and Molybdenum enhances rat thyroid cell transformation. In: Journal of Experimental and Clinical Cancer Research. 2017 ; Vol. 36, No. 1. pp. 73.
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T1 - Intake of Boron, Cadmium, and Molybdenum enhances rat thyroid cell transformation

AU - Luca, E.

AU - Fici, L.

AU - Ronchi, A.

AU - Marandino, F.

AU - Rossi, E. D.

AU - Caristo, M. E.

AU - Malandrino, P.

AU - Russo, M.

AU - Pontecorvi, A.

AU - Vigneri, R.

AU - Moretti, Fabiola

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Y1 - 2017/6/2

N2 - BACKGROUND: Epidemiologic data in volcanic areas suggest that environmental factors might be involved in the increase of thyroid cancer (TC) incidence. Recent reports indicate that several heavy metals and metalloids are increased in volcanic areas. This study aims to evaluate the combined effect of three of these elements Boron (B), Cadmium (Cd), and Molybdenum (Mo) - all increased in the volcanic area of Mt. Etna, in Italy - on thyroid tumorigenesis in the rat. METHODS: Female Wistar rats prone to develop thyroid tumors by low-iodine diet and methimazole treatment received ad libitum drinking water supplemented with B, Cd, and Mo at concentrations in the range found in the urine samples of residents of the volcanic area. At 5 and 10 months animals were euthanized, and their thyroid analysed. Statistical analysis was performed with a 2-way unpaired t-test. RESULTS: No toxic effect of the three elements on the growth of the animals was observed. A significant increase of histological features of transformation was observed in thyroid follicular cells of rats treated with B, Cd, and Mo compared with those of control group. These abnormalities were associated with decreased iodine content in the thyroid. CONCLUSIONS: This study provides the evidence that slightly increased environmental concentrations of B, Cd, and Mo can accelerate the appearance of transformation marks in the thyroid gland of hypothyroid rats.

AB - BACKGROUND: Epidemiologic data in volcanic areas suggest that environmental factors might be involved in the increase of thyroid cancer (TC) incidence. Recent reports indicate that several heavy metals and metalloids are increased in volcanic areas. This study aims to evaluate the combined effect of three of these elements Boron (B), Cadmium (Cd), and Molybdenum (Mo) - all increased in the volcanic area of Mt. Etna, in Italy - on thyroid tumorigenesis in the rat. METHODS: Female Wistar rats prone to develop thyroid tumors by low-iodine diet and methimazole treatment received ad libitum drinking water supplemented with B, Cd, and Mo at concentrations in the range found in the urine samples of residents of the volcanic area. At 5 and 10 months animals were euthanized, and their thyroid analysed. Statistical analysis was performed with a 2-way unpaired t-test. RESULTS: No toxic effect of the three elements on the growth of the animals was observed. A significant increase of histological features of transformation was observed in thyroid follicular cells of rats treated with B, Cd, and Mo compared with those of control group. These abnormalities were associated with decreased iodine content in the thyroid. CONCLUSIONS: This study provides the evidence that slightly increased environmental concentrations of B, Cd, and Mo can accelerate the appearance of transformation marks in the thyroid gland of hypothyroid rats.

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KW - Cadmium

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KW - Molybdenum

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KW - Thyroid cancer

KW - Thyroid nodules

KW - Volcanic area

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