Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition. International journal of cancer

Aurora Perez-Cornago, Inge Huybrechts, Paul N. Appleby, Julie A. Schmidt, Francesca L. Crowe, Kim Overvad, Anne Tjønneland, Tilman Kühn, Verena Katzke, Antonia Trichopoulou, Anna Karakatsani, Eleni Peppa, Sara Grioni, Domenico Palli, Carlotta Sacerdote, Rosario Tumino, H. Bas Bueno-de-Mesquita, Nerea Larrañaga, Maria-Jose Sánchez, J. Ramón QuirósEva Ardanaz, María-Dolores Chirlaque, Antonio Agudo, Anders Bjartell, Peter Wallström, Veronique Chajes, Konstantinos K. Tsilidis, Dagfinn Aune, Elio Riboli, Ruth C. Travis, Timothy J. Key

Research output: Contribution to journalArticlepeer-review

Abstract

The associations of individual dietary fatty acids with prostate cancer risk have not been examined comprehensively. We examined the prospective association of individual dietary fatty acids with prostate cancer risk overall, by tumor subtypes, and prostate cancer death. 142,239 men from the European Prospective Investigation into Cancer and Nutrition who were free from cancer at recruitment were included. Dietary intakes of individual fatty acids were estimated using center-specific validated dietary questionnaires at baseline and calibrated with 24-h recalls. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow-up of 13.9 years, 7,036 prostate cancer cases and 936 prostate cancer deaths were ascertained. Intakes of individual fatty acids were not related to overall prostate cancer risk. There was evidence of heterogeneity in the association of some short chain saturated fatty acids with prostate cancer risk by tumor stage (p(heterogeneity)
Original languageEnglish
Pages (from-to)44-57
Number of pages14
JournalInternational Journal of Cancer
Volume146
Issue number1
DOIs
Publication statusPublished - 2020

Keywords

  • Adult
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Aged
  • *individual fatty acids
  • *prospective
  • *prostate cancer
  • *tumor subtypes
  • Dietary Fats/*administration & dosage
  • Fatty Acids/*administration & dosage
  • Prostatic Neoplasms/*epidemiology

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