Intake of selected micronutrients and the risk of breast cancer

Eva Negri, Carlo La Vecchia, Silvia Franceschi, Barbara D'Avanzo, Renato Talamini, Maria Parpinel, Monica Ferraroni, Rosa Filiberti, Maurizio Montella, Fabio Falcini, Ettore Conti, Adriano Decarli

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

To investigate the relation between selected micronutrients and breast cancer risk, we conducted a case-control study of breast cancer between June 1991 and April 1994 in 6 Italian areas. The study included 2569 women admitted to the major teaching and general hospitals of the study areas with histologically confirmed incident breast cancer and 2588 control women with no history of cancer, who were admitted to hospitals in the same catchment areas for acute, non-neoplastic, nongynecological conditions unrelated to hormonal or digestive tract diseases or to long-term modifications of the diet. Dietary habits, including alcoholic beverage consumption, were investigated using a validated food frequency questionnaire, including 78 foods or food groups, several types of alcoholic beverages, some 'fat intake pattern' questions and some open sections for foods consumed frequently by the subject and not reported in the questionnaire. To control for potential confounding factors, several multiple logistic regression models were used. When major correlates, energy intake and the mutual confounding effect of the various micronutrients were taken into account, beta-carotene, vitamin E and calcium showed a significant inverse association with breast cancer risk. The estimated odds ratios of the 5th quintile compared to the lowest one were 0.84 for beta-carotene, 0.75 for vitamin E and 0.81 for calcium. No significant association emerged for retinol, vitamin C, thiamin, riboflavin, iron and potassium. Our results suggest that a diet rich in several micronutrients, particularly beta-carotene, vitamin E and calcium, may be protective against breast cancer.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalInternational Journal of Cancer
Volume65
Issue number2
DOIs
Publication statusPublished - Jan 17 1996

Fingerprint

Micronutrients
Breast Neoplasms
beta Carotene
Vitamin E
Food
Alcoholic Beverages
Calcium
Logistic Models
Diet Therapy
Riboflavin
Thiamine
Feeding Behavior
Energy Intake
Vitamin A
Teaching Hospitals
General Hospitals
Ascorbic Acid
Gastrointestinal Tract
Case-Control Studies
Potassium

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Intake of selected micronutrients and the risk of breast cancer. / Negri, Eva; La Vecchia, Carlo; Franceschi, Silvia; D'Avanzo, Barbara; Talamini, Renato; Parpinel, Maria; Ferraroni, Monica; Filiberti, Rosa; Montella, Maurizio; Falcini, Fabio; Conti, Ettore; Decarli, Adriano.

In: International Journal of Cancer, Vol. 65, No. 2, 17.01.1996, p. 140-144.

Research output: Contribution to journalArticle

Negri, Eva ; La Vecchia, Carlo ; Franceschi, Silvia ; D'Avanzo, Barbara ; Talamini, Renato ; Parpinel, Maria ; Ferraroni, Monica ; Filiberti, Rosa ; Montella, Maurizio ; Falcini, Fabio ; Conti, Ettore ; Decarli, Adriano. / Intake of selected micronutrients and the risk of breast cancer. In: International Journal of Cancer. 1996 ; Vol. 65, No. 2. pp. 140-144.
@article{6ebf3f65905d4cd387bdbc69e0350453,
title = "Intake of selected micronutrients and the risk of breast cancer",
abstract = "To investigate the relation between selected micronutrients and breast cancer risk, we conducted a case-control study of breast cancer between June 1991 and April 1994 in 6 Italian areas. The study included 2569 women admitted to the major teaching and general hospitals of the study areas with histologically confirmed incident breast cancer and 2588 control women with no history of cancer, who were admitted to hospitals in the same catchment areas for acute, non-neoplastic, nongynecological conditions unrelated to hormonal or digestive tract diseases or to long-term modifications of the diet. Dietary habits, including alcoholic beverage consumption, were investigated using a validated food frequency questionnaire, including 78 foods or food groups, several types of alcoholic beverages, some 'fat intake pattern' questions and some open sections for foods consumed frequently by the subject and not reported in the questionnaire. To control for potential confounding factors, several multiple logistic regression models were used. When major correlates, energy intake and the mutual confounding effect of the various micronutrients were taken into account, beta-carotene, vitamin E and calcium showed a significant inverse association with breast cancer risk. The estimated odds ratios of the 5th quintile compared to the lowest one were 0.84 for beta-carotene, 0.75 for vitamin E and 0.81 for calcium. No significant association emerged for retinol, vitamin C, thiamin, riboflavin, iron and potassium. Our results suggest that a diet rich in several micronutrients, particularly beta-carotene, vitamin E and calcium, may be protective against breast cancer.",
author = "Eva Negri and {La Vecchia}, Carlo and Silvia Franceschi and Barbara D'Avanzo and Renato Talamini and Maria Parpinel and Monica Ferraroni and Rosa Filiberti and Maurizio Montella and Fabio Falcini and Ettore Conti and Adriano Decarli",
year = "1996",
month = "1",
day = "17",
doi = "10.1002/(SICI)1097-0215(19960117)65:2<140::AID-IJC3>3.0.CO;2-Z",
language = "English",
volume = "65",
pages = "140--144",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Intake of selected micronutrients and the risk of breast cancer

AU - Negri, Eva

AU - La Vecchia, Carlo

AU - Franceschi, Silvia

AU - D'Avanzo, Barbara

AU - Talamini, Renato

AU - Parpinel, Maria

AU - Ferraroni, Monica

AU - Filiberti, Rosa

AU - Montella, Maurizio

AU - Falcini, Fabio

AU - Conti, Ettore

AU - Decarli, Adriano

PY - 1996/1/17

Y1 - 1996/1/17

N2 - To investigate the relation between selected micronutrients and breast cancer risk, we conducted a case-control study of breast cancer between June 1991 and April 1994 in 6 Italian areas. The study included 2569 women admitted to the major teaching and general hospitals of the study areas with histologically confirmed incident breast cancer and 2588 control women with no history of cancer, who were admitted to hospitals in the same catchment areas for acute, non-neoplastic, nongynecological conditions unrelated to hormonal or digestive tract diseases or to long-term modifications of the diet. Dietary habits, including alcoholic beverage consumption, were investigated using a validated food frequency questionnaire, including 78 foods or food groups, several types of alcoholic beverages, some 'fat intake pattern' questions and some open sections for foods consumed frequently by the subject and not reported in the questionnaire. To control for potential confounding factors, several multiple logistic regression models were used. When major correlates, energy intake and the mutual confounding effect of the various micronutrients were taken into account, beta-carotene, vitamin E and calcium showed a significant inverse association with breast cancer risk. The estimated odds ratios of the 5th quintile compared to the lowest one were 0.84 for beta-carotene, 0.75 for vitamin E and 0.81 for calcium. No significant association emerged for retinol, vitamin C, thiamin, riboflavin, iron and potassium. Our results suggest that a diet rich in several micronutrients, particularly beta-carotene, vitamin E and calcium, may be protective against breast cancer.

AB - To investigate the relation between selected micronutrients and breast cancer risk, we conducted a case-control study of breast cancer between June 1991 and April 1994 in 6 Italian areas. The study included 2569 women admitted to the major teaching and general hospitals of the study areas with histologically confirmed incident breast cancer and 2588 control women with no history of cancer, who were admitted to hospitals in the same catchment areas for acute, non-neoplastic, nongynecological conditions unrelated to hormonal or digestive tract diseases or to long-term modifications of the diet. Dietary habits, including alcoholic beverage consumption, were investigated using a validated food frequency questionnaire, including 78 foods or food groups, several types of alcoholic beverages, some 'fat intake pattern' questions and some open sections for foods consumed frequently by the subject and not reported in the questionnaire. To control for potential confounding factors, several multiple logistic regression models were used. When major correlates, energy intake and the mutual confounding effect of the various micronutrients were taken into account, beta-carotene, vitamin E and calcium showed a significant inverse association with breast cancer risk. The estimated odds ratios of the 5th quintile compared to the lowest one were 0.84 for beta-carotene, 0.75 for vitamin E and 0.81 for calcium. No significant association emerged for retinol, vitamin C, thiamin, riboflavin, iron and potassium. Our results suggest that a diet rich in several micronutrients, particularly beta-carotene, vitamin E and calcium, may be protective against breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=9044238432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9044238432&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0215(19960117)65:2<140::AID-IJC3>3.0.CO;2-Z

DO - 10.1002/(SICI)1097-0215(19960117)65:2<140::AID-IJC3>3.0.CO;2-Z

M3 - Article

C2 - 8567108

AN - SCOPUS:9044238432

VL - 65

SP - 140

EP - 144

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 2

ER -