Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma

Maria Teresa di Martino, Pietro Hiram Guzzi, Daniele Caracciolo, Luca Agnelli, Antonino Neri, Brian A. Walker, Gareth J. Morgan, Mario Cannataro, Pierfrancesco Tassone, Pierosandro Tagliaferri

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple Myeloma (MM) is a malignancy characterized by the hyperdiploid (HD-MM) and the non-hyperdiploid (nHD-MM) subtypes. To shed light within the molecular architecture of these subtypes, we used a novel integromics approach. By annotated MM patient mRNA/microRNA (miRNA) datasets, we investigated mRNAs and miRNAs profiles with relation to changes in transcriptional regulators expression. We found that HD-MM displays specific gene and miRNA expression profiles, involving the Signal Transducer and Activator of Transcription (STAT)3 pathway as well as the Transforming Growth Factor-beta (TGFβ) and the transcription regulator Nuclear Protein-1 (NUPR1). Our data define specific molecular features of HD-MM that may translate in the identification of novel relevant druggable targets.

Original languageEnglish
Pages (from-to)19132-19147
Number of pages16
JournalOncotarget
Volume6
Issue number22
Publication statusPublished - 2015

Keywords

  • Hyperdiploid myeloma
  • Integromics
  • microRNA
  • miRNA
  • Multiple myeloma
  • Transcription factors

ASJC Scopus subject areas

  • Oncology

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