TY - JOUR
T1 - Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma
AU - di Martino, Maria Teresa
AU - Guzzi, Pietro Hiram
AU - Caracciolo, Daniele
AU - Agnelli, Luca
AU - Neri, Antonino
AU - Walker, Brian A.
AU - Morgan, Gareth J.
AU - Cannataro, Mario
AU - Tassone, Pierfrancesco
AU - Tagliaferri, Pierosandro
PY - 2015
Y1 - 2015
N2 - Multiple Myeloma (MM) is a malignancy characterized by the hyperdiploid (HD-MM) and the non-hyperdiploid (nHD-MM) subtypes. To shed light within the molecular architecture of these subtypes, we used a novel integromics approach. By annotated MM patient mRNA/microRNA (miRNA) datasets, we investigated mRNAs and miRNAs profiles with relation to changes in transcriptional regulators expression. We found that HD-MM displays specific gene and miRNA expression profiles, involving the Signal Transducer and Activator of Transcription (STAT)3 pathway as well as the Transforming Growth Factor-beta (TGFβ) and the transcription regulator Nuclear Protein-1 (NUPR1). Our data define specific molecular features of HD-MM that may translate in the identification of novel relevant druggable targets.
AB - Multiple Myeloma (MM) is a malignancy characterized by the hyperdiploid (HD-MM) and the non-hyperdiploid (nHD-MM) subtypes. To shed light within the molecular architecture of these subtypes, we used a novel integromics approach. By annotated MM patient mRNA/microRNA (miRNA) datasets, we investigated mRNAs and miRNAs profiles with relation to changes in transcriptional regulators expression. We found that HD-MM displays specific gene and miRNA expression profiles, involving the Signal Transducer and Activator of Transcription (STAT)3 pathway as well as the Transforming Growth Factor-beta (TGFβ) and the transcription regulator Nuclear Protein-1 (NUPR1). Our data define specific molecular features of HD-MM that may translate in the identification of novel relevant druggable targets.
KW - Hyperdiploid myeloma
KW - Integromics
KW - microRNA
KW - miRNA
KW - Multiple myeloma
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=84938885920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938885920&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84938885920
VL - 6
SP - 19132
EP - 19147
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 22
ER -