Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array

Ivo Kwee, Andrea Rinaldi, Paola Rancoita, Davide Rossi, Daniela Capello, Francesco Forconi, Nicola Giuliani, Roberto Piva, Giorgio Inghirami, Gianluca Gaidano, Emanuele Zucca, Francesco Bertoni

Research output: Contribution to journalArticle

Abstract

Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles to those obtained with a standard technique in a series of diffuse large B-cell lymphomas: the profiles showed a high degree of consensus. The demonstration of CN profiling as an additional function of the IIM assay may impact the choice of platform for methylation profiling of haematological and solid tumours.

Original languageEnglish
Pages (from-to)354-357
Number of pages4
JournalBritish Journal of Haematology
Volume156
Issue number3
DOIs
Publication statusPublished - Feb 2012

Keywords

  • ArrayCGH
  • Illumina Infinium Methylation
  • Malignant lymphomas
  • Methylation

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Kwee, I., Rinaldi, A., Rancoita, P., Rossi, D., Capello, D., Forconi, F., Giuliani, N., Piva, R., Inghirami, G., Gaidano, G., Zucca, E., & Bertoni, F. (2012). Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array. British Journal of Haematology, 156(3), 354-357. https://doi.org/10.1111/j.1365-2141.2011.08946.x