Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease

A Gupta, VR Taqueti, TP van de Hoef, NS Bajaj, PE Bravo, VL Murthy, MT Osborne, SB Seidelmann, T Vita, CF Bibbo, M Harrington, J Hainer, O Rimoldi, S Dorbala, DL Bhatt, R Blankstein, PG Camici, MF Di Carli

Research output: Contribution to journalArticle

Abstract

BACKGROUND: It is suggested that the integration of maximal myocardial blood flow (MBF) and coronary flow reserve (CFR), termed coronary flow capacity, allows for comprehensive evaluation of patients with known or suspected stable coronary artery disease. Because management decisions are predicated on clinical risk, we sought to determine the independent and integrated value of maximal MBF and CFR for predicting cardiovascular death. METHODS: MBF and CFR were quantified in 4029 consecutive patients (median age 66 years, 50.5% women) referred for rest/stress myocardial perfusion positron emission tomography scans from January 2006 to December 2013. The primary outcome was cardiovascular mortality. Maximal MBF
Original languageEnglish
Pages (from-to)2325-2336
Number of pages12
JournalCirculation
Volume136
Issue number24
DOIs
Publication statusPublished - 2017

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    Gupta, A., Taqueti, VR., van de Hoef, TP., Bajaj, NS., Bravo, PE., Murthy, VL., Osborne, MT., Seidelmann, SB., Vita, T., Bibbo, CF., Harrington, M., Hainer, J., Rimoldi, O., Dorbala, S., Bhatt, DL., Blankstein, R., Camici, PG., & Di Carli, MF. (2017). Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease. Circulation, 136(24), 2325-2336. https://doi.org/10.1161/CIRCULATIONAHA.117.029992