Integrated profiling of diffuse large B-cell lymphoma with 7q gain

Ekaterina Chigrinova, Michael Mian, Yulei Shen, Timothy C. Greiner, Wing C. Chan, Julie M. Vose, Giorgio Inghirami, Annalisa Chiappella, Luca Baldini, Maurilio Ponzoni, Andrés J M Ferreri, Silvia Franceschetti, Gianluca Gaidano, Alessandra Tucci, Fabio Facchetti, Thierry Lazure, Olivier Lambotte, Santiago Montes-Moreno, Miguel A. Piris, Emanuele ZuccaIvo Kwee, Francesco Bertoni

Research output: Contribution to journalArticlepeer-review

Abstract

To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

Original languageEnglish
Pages (from-to)499-503
Number of pages5
JournalBritish Journal of Haematology
Volume153
Issue number4
DOIs
Publication statusPublished - May 2011

Keywords

  • Affymetrix
  • Aggressive lymphoma
  • Bone marrow
  • Gain
  • MiRNA

ASJC Scopus subject areas

  • Hematology

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