Progetto integrato per la ricerca translazionale nel carcinoma duttale del pancreas.

Translated title of the contribution: Integrated project for the translational research on pancreatic ductal carcinoma

Stefano Marcucci, Antonio Bonora, Massimo Falconi, Claudio Sorio, Simonetta Orlandini, Stefania Beghelli, Patrizia Cristofori, Gianni Dal Negro, Pier Nicola Marchiori, Claudio Bassi, Aldo Scarpa, Paolo Pederzoli

Research output: Contribution to journalArticle

Abstract

The narrow chances of therapy and the poor prognosis of pancreatic cancer make basic research a crucial way for both a better knowledge and a possible improvement in the treatment of this disease. The very limited availability of pancreatic specimen for genetic and biological studies forced the researchers to plan "in vitro" and "in vivo" models in order to overcome this handicap. Among the animal models, the one according to Fu et al. seemed to be the most helpful and effective approach. Nevertheless, being this model complex and failing in main perspective applications, an enlarged project perpetuating B-lymphocytes of the patients, successfully xenografting from vitally criopreserved specimen and developing cell lines from xenografts was planned. According to the aim of our project, a really perpetual and renewable bank of tumoral and normal tissue from patients suffering from pancreatic carcinoma was obtained. This model is also expected to be an effective approach for the evaluation of experimental chemotherapeutic schedules and new gene therapy assessment.

Translated title of the contributionIntegrated project for the translational research on pancreatic ductal carcinoma
Original languageItalian
Pages (from-to)845-854
Number of pages10
JournalChirurgia Italiana
Volume54
Issue number6
Publication statusPublished - Nov 2002

ASJC Scopus subject areas

  • Surgery

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    Marcucci, S., Bonora, A., Falconi, M., Sorio, C., Orlandini, S., Beghelli, S., Cristofori, P., Dal Negro, G., Marchiori, P. N., Bassi, C., Scarpa, A., & Pederzoli, P. (2002). Progetto integrato per la ricerca translazionale nel carcinoma duttale del pancreas. Chirurgia Italiana, 54(6), 845-854.