Integrated regulation of signal coding and plasticity by NMDA receptors at a central synapse

Egidio D'Angelo, Paola Rossi

Research output: Contribution to journalArticle

Abstract

The role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended. NMDA receptor-mediated currents, apart from their Ca2+ permeability, show a marked voltage dependence, consisting of current increase and slowdown during membrane depolarization. During high-frequency synaptic transmission, NMDA current increase and slowdown are primed by non-NMDA receptor-dependent depolarization and proceed regeneratively. Thus, NMDA receptors make a decisive contribution to membrane depolarization and spike-firing. From the data obtained at the messy fiber-granule cell synapse of the cerebellum, we propose that the electrogenic role of NMDA receptors is functional to LTP induction. Moreover, during LTP, both NMDA and non-NMDA receptor currents are potentiated, thus establishing a feed-forward mechanism that ultimately enhances spike firing. Thus, NMDA receptors exert an integrated control on signal coding and plasticity. This mechanism may have important implications for information processing at the cerebellar messy fiber-granule cell relay.

Original languageEnglish
Pages (from-to)8-16
Number of pages9
JournalNeural Plasticity
Volume6
Issue number3
DOIs
Publication statusPublished - 1998

Fingerprint

N-Methyl-D-Aspartate Receptors
Synapses
N-Methylaspartate
Membranes
Long-Term Potentiation
Glutamate Receptors
Automatic Data Processing
Synaptic Transmission
Cerebellum
Permeability

Keywords

  • Cerebellum granule cells
  • LTP
  • NMDA receptors
  • Synaptic transmission

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Integrated regulation of signal coding and plasticity by NMDA receptors at a central synapse. / D'Angelo, Egidio; Rossi, Paola.

In: Neural Plasticity, Vol. 6, No. 3, 1998, p. 8-16.

Research output: Contribution to journalArticle

@article{e951bc296bd04158b692ea896499fdac,
title = "Integrated regulation of signal coding and plasticity by NMDA receptors at a central synapse",
abstract = "The role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended. NMDA receptor-mediated currents, apart from their Ca2+ permeability, show a marked voltage dependence, consisting of current increase and slowdown during membrane depolarization. During high-frequency synaptic transmission, NMDA current increase and slowdown are primed by non-NMDA receptor-dependent depolarization and proceed regeneratively. Thus, NMDA receptors make a decisive contribution to membrane depolarization and spike-firing. From the data obtained at the messy fiber-granule cell synapse of the cerebellum, we propose that the electrogenic role of NMDA receptors is functional to LTP induction. Moreover, during LTP, both NMDA and non-NMDA receptor currents are potentiated, thus establishing a feed-forward mechanism that ultimately enhances spike firing. Thus, NMDA receptors exert an integrated control on signal coding and plasticity. This mechanism may have important implications for information processing at the cerebellar messy fiber-granule cell relay.",
keywords = "Cerebellum granule cells, LTP, NMDA receptors, Synaptic transmission",
author = "Egidio D'Angelo and Paola Rossi",
year = "1998",
doi = "10.1155/NP.1998.8",
language = "English",
volume = "6",
pages = "8--16",
journal = "Neural Plasticity",
issn = "2090-5904",
publisher = "Hindawi Publishing Corporation",
number = "3",

}

TY - JOUR

T1 - Integrated regulation of signal coding and plasticity by NMDA receptors at a central synapse

AU - D'Angelo, Egidio

AU - Rossi, Paola

PY - 1998

Y1 - 1998

N2 - The role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended. NMDA receptor-mediated currents, apart from their Ca2+ permeability, show a marked voltage dependence, consisting of current increase and slowdown during membrane depolarization. During high-frequency synaptic transmission, NMDA current increase and slowdown are primed by non-NMDA receptor-dependent depolarization and proceed regeneratively. Thus, NMDA receptors make a decisive contribution to membrane depolarization and spike-firing. From the data obtained at the messy fiber-granule cell synapse of the cerebellum, we propose that the electrogenic role of NMDA receptors is functional to LTP induction. Moreover, during LTP, both NMDA and non-NMDA receptor currents are potentiated, thus establishing a feed-forward mechanism that ultimately enhances spike firing. Thus, NMDA receptors exert an integrated control on signal coding and plasticity. This mechanism may have important implications for information processing at the cerebellar messy fiber-granule cell relay.

AB - The role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended. NMDA receptor-mediated currents, apart from their Ca2+ permeability, show a marked voltage dependence, consisting of current increase and slowdown during membrane depolarization. During high-frequency synaptic transmission, NMDA current increase and slowdown are primed by non-NMDA receptor-dependent depolarization and proceed regeneratively. Thus, NMDA receptors make a decisive contribution to membrane depolarization and spike-firing. From the data obtained at the messy fiber-granule cell synapse of the cerebellum, we propose that the electrogenic role of NMDA receptors is functional to LTP induction. Moreover, during LTP, both NMDA and non-NMDA receptor currents are potentiated, thus establishing a feed-forward mechanism that ultimately enhances spike firing. Thus, NMDA receptors exert an integrated control on signal coding and plasticity. This mechanism may have important implications for information processing at the cerebellar messy fiber-granule cell relay.

KW - Cerebellum granule cells

KW - LTP

KW - NMDA receptors

KW - Synaptic transmission

UR - http://www.scopus.com/inward/record.url?scp=0032323359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032323359&partnerID=8YFLogxK

U2 - 10.1155/NP.1998.8

DO - 10.1155/NP.1998.8

M3 - Article

C2 - 9920678

AN - SCOPUS:0032323359

VL - 6

SP - 8

EP - 16

JO - Neural Plasticity

JF - Neural Plasticity

SN - 2090-5904

IS - 3

ER -