Integrated testing strategy (ITS) for bioaccumulation assessment under REACH

Anna Lombardo, Alessandra Roncaglioni, Emilio Benfentati, Monika Nendza, Helmut Segner, Alberto Fernández, Ralph Kühne, Antonio Franco, Eduard Pauné, Gerrit Schüürmann

Research output: Contribution to journalArticle

Abstract

REACH (registration, evaluation, authorisation and restriction of chemicals) regulation requires that all the chemicals produced or imported in Europe above 1 tonne/year are registered. To register a chemical, physicochemical, toxicological and ecotoxicological information needs to be reported in a dossier. REACH promotes the use of alternative methods to replace, refine and reduce the use of animal (eco)toxicity testing. Within the EU OSIRIS project, integrated testing strategies (ITSs) have been developed for the rational use of non-animal testing approaches in chemical hazard assessment. Here we present an ITS for evaluating the bioaccumulation potential of organic chemicals. The scheme includes the use of all available data (also the non-optimal ones), waiving schemes, analysis of physicochemical properties related to the end point and alternative methods (both in silico and in vitro). In vivo methods are used only as last resort. Using the ITS, in vivo testing could be waived for about 67% of the examined compounds, but bioaccumulation potential could be estimated on the basis of non-animal methods. The presented ITS is freely available through a web tool.

Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalEnvironment International
Volume69
DOIs
Publication statusPublished - 2014

Fingerprint

bioaccumulation
OSIRIS
physicochemical property
hazard assessment
evaluation
chemical
registration
authorisation
method
animal

Keywords

  • Alternative methods
  • Bioaccumulation
  • In silico methods
  • Integrated testing strategy
  • REACH
  • Reduce animal testing

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Integrated testing strategy (ITS) for bioaccumulation assessment under REACH. / Lombardo, Anna; Roncaglioni, Alessandra; Benfentati, Emilio; Nendza, Monika; Segner, Helmut; Fernández, Alberto; Kühne, Ralph; Franco, Antonio; Pauné, Eduard; Schüürmann, Gerrit.

In: Environment International, Vol. 69, 2014, p. 40-50.

Research output: Contribution to journalArticle

Lombardo, A, Roncaglioni, A, Benfentati, E, Nendza, M, Segner, H, Fernández, A, Kühne, R, Franco, A, Pauné, E & Schüürmann, G 2014, 'Integrated testing strategy (ITS) for bioaccumulation assessment under REACH', Environment International, vol. 69, pp. 40-50. https://doi.org/10.1016/j.envint.2014.04.005
Lombardo, Anna ; Roncaglioni, Alessandra ; Benfentati, Emilio ; Nendza, Monika ; Segner, Helmut ; Fernández, Alberto ; Kühne, Ralph ; Franco, Antonio ; Pauné, Eduard ; Schüürmann, Gerrit. / Integrated testing strategy (ITS) for bioaccumulation assessment under REACH. In: Environment International. 2014 ; Vol. 69. pp. 40-50.
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